{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:17:13Z","timestamp":1791267433280,"version":"4.1.0"},"reference-count":29,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,9,9]]},"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>The aims of this study were to describe the clinical, biological and radiological features of community-acquired (CA) Legionnaires\u2019 disease (LD) and identify the predictors of mortality in hospitalised patients.<\/jats:p>\n                  <jats:p>Demographic data, risk factors, clinical and biological features, medical management, complications, and outcome from 540 hospitalised patients with confirmed CA LD were prospectively recorded.<\/jats:p>\n                  <jats:p>\n                    8.1% of patients (44 out of 540) died. The predictors of survival after Kaplan\u2013Meier analysis were male sex (p=0.01), age &lt;60 yrs (p=0.02), general symptoms (p=0.006), intensive care unit (ICU) stay (p&lt;0.001), and class II\u2013III Pneumonia Severity Index score (p=0.004). Six predictors of death were identified by multivariate analysis: age (per 10-yr increment) (relative hazard (RH) 1.50, 95% CI 1.21\u20131.87), female sex (RH 2.00, 95% CI 1.08\u20133.69), ICU admission (RH 3.31, 95% CI 1.67\u20136.56), renal failure (RH 2.73, 95% CI 1.42\u20135.27), corticosteroid therapy (RH 2.54, 95% CI 1.04\u20136.20) and C-reactive protein (CRP) &gt;500 mg\u00b7L\n                    <jats:sup>\u22121<\/jats:sup>\n                    (RH 2.14, 95% CI 1.02\u20134.48). Appropriate antibiotic therapy was prescribed for 70.8% (292 out of 412) of patients after admission and for 99.8% (537 out of 538) of patients after diagnosis confirmation.\n                  <\/jats:p>\n                  <jats:p>In conclusion, female sex, age, ICU stay, renal failure, corticosteroid treatment and increased level of CRP are significant risk factors for mortality in CA LD.<\/jats:p>","DOI":"10.1183\/09031936.00076911","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T00:27:52Z","timestamp":1318897672000},"page":"963-970","source":"Crossref","is-referenced-by-count":63,"title":["Factors associated with hospital mortality in community-acquired legionellosis in France"],"prefix":"10.1183","volume":"39","author":[{"given":"C.","family":"Chidiac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pires-Cronenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jarraud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Camp\u00e8se","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bissery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Weinbreck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Brun-Buisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-P.","family":"Sollet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ecochard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-C.","family":"Desenclos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Etienne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vanhems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the French Legionnaires\u2019 Disease Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2011,10,17]]},"reference":[{"key":"2024102020534629000_39.4.963.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197712012972201"},{"key":"2024102020534629000_39.4.963.2","unstructured":"Edelstein P Cianciotto NP . Legionellosis. In: Mandell GL Bennett JE Dolin R , eds. Principles and Practice of Infectious Diseases. 7th Edn. Philadephia, Elsevier-Churchill Livingstone, 2010; pp. 2969\u20132971."},{"key":"2024102020534629000_39.4.963.3","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268807000283"},{"key":"2024102020534629000_39.4.963.4","first-page":"185","article-title":"Les l\u00e9gionelloses survenues en France en 2005 [Legionellosis occurred in France in 2005]","volume":"26","author":"Campese","year":"2006","journal-title":"Bulletin Epidemiologique Hebdomadaire"},{"key":"2024102020534629000_39.4.963.5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.medmal.2007.03.015","article-title":"Factors associated with mortality in Legionnaires' disease, France, 2002\u20132004","volume":"37","author":"Poupard","year":"2007","journal-title":"Med Mal Infect"},{"key":"2024102020534629000_39.4.963.6","first-page":"342","article-title":"Les l\u00e9gionelloses survenues en France en 2008. 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