{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:36:59Z","timestamp":1761561419752,"version":"3.37.3"},"reference-count":35,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2010,3,22]]},"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p>Sleep-related disorders represent an important health burden and their prevalence increases with age. In patients with snoring or sleepiness, the presence of expiratory flow limitation (EFL), determined<jats:italic>via<\/jats:italic>the negative expiratory pressure (NEP) method, is related to the apnoea\/hypopnoea index (AHI). In this study, we examined whether EFL can be used to predict obstructive sleep apnoea syndrome (OSAS) in healthy asymptomatic older subjects.<\/jats:p><jats:p>A group of 72-yr-old subjects (n = 448, 44% males) with a mean body mass index of 25.5\u00b13.8 kg\u00b7m<jats:sup>\u22122<\/jats:sup>were examined. All subjects underwent spirometry, NEP (-5 cmH<jats:sub>2<\/jats:sub>O, sitting position) and ventilatory polygraphy (VP).<\/jats:p><jats:p>Spirometry was within normal values in 88% of the group and EFL was present in 143 (32%) subjects with a higher prevalence in females (89 out of 249<jats:italic>versus<\/jats:italic>54 out of 199 in females and males, respectively). VP showed an AHI&lt;15 h<jats:sup>\u22121<\/jats:sup>in 238 subjects (53%) and OSAS with an AHI \u226515 h<jats:sup>\u22121<\/jats:sup>in 47%. EFL was found in 15% of subjects with OSAS. Consequently, EFL had low sensitivity and specificity in the prediction of OSAS (31.4% and 67.7%, respectively).<\/jats:p><jats:p>We conclude that the prevalence of EFL is elevated in healthy older subjects and cannot be used to predict the presence of sleep-related disorders in an older population.<\/jats:p>","DOI":"10.1183\/09031936.00078009","type":"journal-article","created":{"date-parts":[[2010,4,9]],"date-time":"2010-04-09T00:31:56Z","timestamp":1270773116000},"page":"842-848","source":"Crossref","is-referenced-by-count":4,"title":["Is tidal expiratory flow limitation predictive of sleep-related disorders in the elderly?"],"prefix":"10.1183","volume":"36","author":[{"given":"M.","family":"Guillot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Costes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Sforza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Maudoux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bertoletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.","family":"Barth\u00e9l\u00e9my","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Roche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2010,4,8]]},"reference":[{"key":"2024102020161945000_36.4.842.1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1164\/ajrccm.163.3.2005065","article-title":"Obstructive sleep apnea\u00e2\u0080\u0093hypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr","volume":"163","author":"Duran","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102020161945000_36.4.842.2","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0140-6736(05)71141-7","article-title":"Long-term cardiovascular outcomes in men with obstructive sleep apnoea\u00e2\u0080\u0093hypopnoea with or without treatment with continuous positive airway pressure: an observational study","volume":"365","author":"Marin","year":"2005","journal-title":"Lancet"},{"key":"2024102020161945000_36.4.842.3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000108914","article-title":"Autonomic nervous system activity and decline as prognostic indicators of cardiovascular and cerebrovascular events: the \u00e2\u0080\u009cPROOF\u00e2\u0080\u009d Study. 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