{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:48:58Z","timestamp":1792158538893,"version":"4.4.0"},"reference-count":37,"publisher":"European Respiratory Society (ERS)","issue":"6","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["7\/8-1"],"award-info":[{"award-number":["7\/8-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["publications.ersnet.org"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2014,11,6]]},"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>Sphingolipids are involved in the pathogenesis of inflammatory diseases. The central molecule is ceramide, which can be converted into ceramide-1-phosphate (C1P). Although C1P can exert anti- and pro-inflammatory effects, its influence on cigarette smoke (CS)-induced lung inflammation is unknown. We aimed to clarify the role of C1P in the pathogenesis of CS-triggered pulmonary inflammation and emphysema in humans and mice.<\/jats:p><jats:p>The effects of C1P were addressed on CS-induced lung inflammation in C57BL\/6 mice, CS extract-triggered activation of human airway epithelial cells (AECs) and neutrophils from patients with chronic obstructive pulmonary disease. Differential cell counts in bronchoalveolar lavage fluid were determined by flow cytometry and pro-inflammatory cytokines were measured by ELISA. Expression and DNA binding of nuclear factor (NF)-\u03baB and neutral sphingomyelinase (nSMase) were quantified by PCR, electrophoretic mobility shift and fluorometric assays.<\/jats:p><jats:p>C1P reduced CS-induced acute and chronic lung inflammation and development of emphysema in mice, which was associated with a reduction in nSMase and NF-\u03baB activity in the lungs. nSMase activity in human serum correlated negatively with forced expiratory volume in 1\u2005s % predicted. In human AECs and neutrophils, C1P inhibited CS-induced activation of NF-\u03baB and nSMase, and reduced pro-inflammatory cytokine release.<\/jats:p><jats:p>Our results suggest that C1P is a potential target for anti-inflammatory treatment in CS-induced lung inflammation.<\/jats:p>","DOI":"10.1183\/09031936.00080014","type":"journal-article","created":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T04:28:11Z","timestamp":1421987291000},"page":"1669-1680","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":54,"title":["Ceramide-1-phosphate inhibits cigarette smoke-induced airway inflammation"],"prefix":"10.1183","volume":"45","author":[{"given":"Kristin","family":"Baudi\u00df","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemil Korcan","family":"Ayata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsofia","family":"Lazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Cicko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Beckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Zech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo Paula","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bittman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"G\u00f3mez-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irmgard","family":"Merfort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Idzko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2015,1,22]]},"reference":[{"key":"2024102023161238000_45.6.1669.1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Updated 2014. www.goldcopd.com\/uploads\/users\/files\/GOLD_Report_2014_Oct30.pdf Date last updated: 2014. Date last accessed: January 8, 2014."},{"key":"2024102023161238000_45.6.1669.2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00040703"},{"key":"2024102023161238000_45.6.1669.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1106955"},{"key":"2024102023161238000_45.6.1669.4","doi-asserted-by":"crossref","first-page":"21128","DOI":"10.1016\/S0021-9258(17)45336-1","article-title":"Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines","volume":"265","author":"Mukaida","year":"1990","journal-title":"J Biol Chem"},{"key":"2024102023161238000_45.6.1669.5","doi-asserted-by":"publisher","DOI":"10.1038\/nm1238"},{"key":"2024102023161238000_45.6.1669.6","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0174OC"},{"key":"2024102023161238000_45.6.1669.7","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00385.2010"},{"key":"2024102023161238000_45.6.1669.8","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-9-1"},{"key":"2024102023161238000_45.6.1669.9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28295"},{"key":"2024102023161238000_45.6.1669.10","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02637"},{"key":"2024102023161238000_45.6.1669.11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1194\/jlr.M300158-JLR200","article-title":"Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages","volume":"45","author":"Gomez-Munoz","year":"2004","journal-title":"J Lipid Res"},{"key":"2024102023161238000_45.6.1669.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2009.01.023"},{"key":"2024102023161238000_45.6.1669.13","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00031.2009"},{"key":"2024102023161238000_45.6.1669.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.02928.x"},{"key":"2024102023161238000_45.6.1669.15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00480.2012"},{"key":"2024102023161238000_45.6.1669.16","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0038OC"},{"key":"2024102023161238000_45.6.1669.17","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0904042"},{"key":"2024102023161238000_45.6.1669.18","first-page":"2327","article-title":"Activation of interleukin-6 gene expression through the NF-kappa B transcription factor","volume":"10","author":"Libermann","year":"1990","journal-title":"Mol Cell Biol"},{"key":"2024102023161238000_45.6.1669.19","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00201.2005"},{"key":"2024102023161238000_45.6.1669.20","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00272002"},{"key":"2024102023161238000_45.6.1669.21","doi-asserted-by":"publisher","DOI":"10.1038\/nm1748"},{"key":"2024102023161238000_45.6.1669.22","doi-asserted-by":"publisher","DOI":"10.1124\/mi.5.6.8"},{"key":"2024102023161238000_45.6.1669.23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.21.10193"},{"key":"2024102023161238000_45.6.1669.24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00281.x"},{"key":"2024102023161238000_45.6.1669.25","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.392"},{"key":"2024102023161238000_45.6.1669.26","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-9-15"},{"key":"2024102023161238000_45.6.1669.27","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.bbalip.2013.02.001","article-title":"New insights on the role of ceramide 1-phosphate in inflammation","volume":"1831","author":"Gomez-Munoz","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"2024102023161238000_45.6.1669.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2008.11.003"},{"key":"2024102023161238000_45.6.1669.29","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M600399-JLR200"},{"key":"2024102023161238000_45.6.1669.30","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201211-2055OC"},{"key":"2024102023161238000_45.6.1669.31","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0422OC"},{"key":"2024102023161238000_45.6.1669.32","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00063112"},{"key":"2024102023161238000_45.6.1669.33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.264010"},{"key":"2024102023161238000_45.6.1669.34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309262200"},{"key":"2024102023161238000_45.6.1669.35","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.028084"},{"key":"2024102023161238000_45.6.1669.36","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4025"},{"key":"2024102023161238000_45.6.1669.37","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21101"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00080014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:55:00Z","timestamp":1740380100000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00080014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,22]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,5,31]]},"published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1183\/09031936.00080014"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00080014","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,22]]}}}