{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:45:56Z","timestamp":1788669956700,"version":"build-2803163510"},"reference-count":36,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2012,11,23]]},"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>We tested the hypotheses that in patients with congestive heart failure (CHF) and sleep disordered breathing (SDB) auto-servoventilation (ASV) improves cardiac function and quality of life.<\/jats:p><jats:p>Between March 2007 and September 2009, patients with stable CHF (left ventricular ejection fraction (LVEF) \u226440%) and SDB (apnoea\/hypopnoea index \u226520 events\u00b7h<jats:sup>\u22121<\/jats:sup>) were randomised to receive either ASV (BiPAP ASV (Philips Respironics, Murrysville, PA, USA), n=37) and optimal medical management, or optimal medical management alone (n=35). Outcomes were assessed at baseline and 12 weeks.<\/jats:p><jats:p>The apnoea\/hypopnoea index assessed with polysomnography scored in one core laboratory was significantly more reduced in the ASV group (-39\u00b116<jats:italic>versus<\/jats:italic>-1\u00b113 events\u00b7h<jats:sup>\u22121<\/jats:sup>; p&lt;0.001) with an average use of 4.5\u00b13.0 h\u00b7day<jats:sup>\u22121<\/jats:sup>. Both groups showed similar improvements of the primary end-point LVEF (+3.4\u00b15<jats:italic>versus<\/jats:italic>+3.5\u00b16%; p=0.915) assessed with echocardiography. In the ASV group, reduction of N-terminal pro-brain natriuretic peptide (NT-proBNP) was significantly greater (-360\u00b1569<jats:italic>versus<\/jats:italic>+135\u00b1625 ng\u00b7mL<jats:sup>\u22121<\/jats:sup>; p=0.010). No differences were observed between the groups in subjective quality of life.<\/jats:p><jats:p>In patients with CHF and SDB, ASV reduced NT-proBNP levels, but improvement of LVEF or quality of life was not greater than in the control group. The data support that such patients can be randomised in large-scale, long-term trials of positive airway pressure therapy<jats:italic>versus<\/jats:italic>control to determine effects on cardiovascular outcome.<\/jats:p>","DOI":"10.1183\/09031936.00083312","type":"journal-article","created":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T05:46:37Z","timestamp":1354859197000},"page":"1244-1254","source":"Crossref","is-referenced-by-count":86,"title":["Auto-servoventilation in heart failure with sleep apnoea: a randomised controlled 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