{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:36:36Z","timestamp":1793190996074,"version":"4.5.0"},"reference-count":35,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2008,10,21]]},"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p>Post-natal exposure to air pollution is associated with diminished lung growth during school age. The current authors aimed to determine whether pre-natal exposure to air pollution is associated with lung function changes in the newborn.<\/jats:p>\n                  <jats:p>\n                    In a prospective birth cohort of 241 healthy term-born neonates, tidal breathing, lung volume, ventilation inhomogeneity and exhaled nitric oxide (eNO) were measured during unsedated sleep at age 5\u2005weeks. Maternal exposure to particles with a 50% cut-off aerodynamic diameter of 10\u2005\u03bcm (PM\n                    <jats:sub>10<\/jats:sub>\n                    ), nitrogen dioxide (NO\n                    <jats:sub>2<\/jats:sub>\n                    ) and ozone (O\n                    <jats:sub>3<\/jats:sub>\n                    ), and distance to major roads were estimated during pregnancy. The association between these exposures and lung function was assessed using linear regression.\n                  <\/jats:p>\n                  <jats:p>\n                    Minute ventilation was higher in infants with higher pre-natal PM\n                    <jats:sub>10<\/jats:sub>\n                    exposure (24.9\u2005mL\u00b7min\n                    <jats:sup>\u22121<\/jats:sup>\n                    per \u03bcg\u00b7m\n                    <jats:sup>\u22123<\/jats:sup>\n                    PM\n                    <jats:sub>10<\/jats:sub>\n                    ). The eNO was increased in infants with higher pre-natal NO\n                    <jats:sub>2<\/jats:sub>\n                    exposure (0.98\u2005ppb per \u03bcg\u00b7m\n                    <jats:sup>\u22123<\/jats:sup>\n                    NO\n                    <jats:sub>2<\/jats:sub>\n                    ). Post-natal exposure to air pollution did not modify these findings. No association was found for pre-natal exposure to O\n                    <jats:sub>3<\/jats:sub>\n                    and lung function parameters.\n                  <\/jats:p>\n                  <jats:p>The present results suggest that pre-natal exposure to air pollution might be associated with higher respiratory need and airway inflammation in newborns. Such alterations during early lung development may be important regarding long-term respiratory morbidity.<\/jats:p>","DOI":"10.1183\/09031936.00084008","type":"journal-article","created":{"date-parts":[[2008,11,14]],"date-time":"2008-11-14T20:34:44Z","timestamp":1226694884000},"page":"594-603","source":"Crossref","is-referenced-by-count":180,"title":["Air pollution during pregnancy and lung function in newborns: a birth cohort study"],"prefix":"10.1183","volume":"33","author":[{"given":"P.","family":"Latzin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"R\u00f6\u00f6sli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Huss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. E.","family":"Kuehni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2008,11,14]]},"reference":[{"key":"2024102019445065000_33.3.594.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040610"},{"key":"2024102019445065000_33.3.594.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60037-3"},{"key":"2024102019445065000_33.3.594.3","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00512001"},{"key":"2024102019445065000_33.3.594.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00089605"},{"key":"2024102019445065000_33.3.594.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073625"},{"key":"2024102019445065000_33.3.594.6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.19.2546-b"},{"key":"2024102019445065000_33.3.594.7","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1289\/ehp.9141","volume":"114","year":"2006","journal-title":"Environ Health Perspect"},{"key":"2024102019445065000_33.3.594.8","unstructured":"Dockery D, Skerrett P, Walters D, Gilliland F. Development of lung function. In: Effects of Air Pollution on Children\u2019s Health and Development \u2013 A Review of the Evidence. Geneva, World Health Organization, 2005; 108\u2013133. www.euro.who.int\/air\/activities\/20060421_1"},{"key":"2024102019445065000_33.3.594.9","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.7.587"},{"key":"2024102019445065000_33.3.594.10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1843.2003.00478.x"},{"key":"2024102019445065000_33.3.594.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2006.04357.x"},{"key":"2024102019445065000_33.3.594.12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.303.6804.671"},{"key":"2024102019445065000_33.3.594.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61379-8"},{"key":"2024102019445065000_33.3.594.14","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200606-782OC"},{"key":"2024102019445065000_33.3.594.15","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16f26.x"},{"key":"2024102019445065000_33.3.594.16","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20674"},{"key":"2024102019445065000_33.3.594.17","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj338"},{"key":"2024102019445065000_33.3.594.18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200412163512517"},{"key":"2024102019445065000_33.3.594.19","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0496(199601)21:1<65::AID-PPUL1950210104>3.0.CO;2-R"},{"key":"2024102019445065000_33.3.594.20","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015973530559"},{"key":"2024102019445065000_33.3.594.21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jes.7500628"},{"key":"2024102019445065000_33.3.594.22","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.1.9001300"},{"key":"2024102019445065000_33.3.594.23","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.078410"},{"key":"2024102019445065000_33.3.594.24","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1080\/10473289.2000.10464161","volume":"50","year":"2000","journal-title":"J Air Waste Manag Assoc"},{"key":"2024102019445065000_33.3.594.25","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-5-36"},{"key":"2024102019445065000_33.3.594.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(99)00048-1"},{"key":"2024102019445065000_33.3.594.27","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2107082"},{"key":"2024102019445065000_33.3.594.28","unstructured":"Holgate S. 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