{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:49:51Z","timestamp":1790668191090,"version":"4.1.0"},"reference-count":21,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":["ersjournals.com"],"crossmark-restriction":true},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2012,10,9]]},"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>We conducted an international, prospective, 3-year questionnaire-based survey among 11 pulmonary hypertension centres to assemble data from patients with pulmonary arterial hypertension (PAH) undergoing noncardiac and nonobstetric surgery.<\/jats:p><jats:p>Data were collected between July 2007 and June 2010 from 114 patients with PAH (70% female, mean age 57 years) who underwent major surgery. At the time of surgery, 43% were in functional class III\/IV. 82% of the interventions were performed under general anaesthesia and 18% under spinal anaesthesia. Major complications occurred in seven (6.1%) of the patients, of whom four died, resulting in an overall perioperative mortality rate of 3.5%. The mortality rate was 15% (two out of 13) in emergency procedures, compared with 2% (two out of 101) in nonemergency procedures (p=0.01). Risk factors for major complications were an elevated right atrial pressure (OR 1.1, 95% CI 1.0\u20131.3; p=0.01), a 6-min walking distance &lt;399 m at the last preoperative assessment (OR 2.2, 95% CI 1.1\u20133.7; p=0.04), the perioperative use of vasopressors (OR 1.5, 95% CI 1.2\u20132.7; p=0.03) and the need for emergency surgery (OR 2.4, 95% CI 1.4\u20133.6; p=0.01).<\/jats:p><jats:p>Major surgery in patients with PAH continues to be a high-risk procedure, particularly when emergency interventions are needed.<\/jats:p>","DOI":"10.1183\/09031936.00089212","type":"journal-article","created":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T03:20:27Z","timestamp":1352431227000},"page":"1302-1307","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":139,"title":["Outcomes of noncardiac, nonobstetric surgery in patients with PAH: an international prospective survey"],"prefix":"10.1183","volume":"41","author":[{"given":"Stephanie","family":"Meyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vallerie V.","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Juergen","family":"Seyfarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M.","family":"Bull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine D.","family":"Vizza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mardi","family":"Gomberg-Maitland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana R.","family":"Preston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan 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