{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:39:10Z","timestamp":1789850350124,"version":"4.0.1"},"reference-count":36,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2008,1,19]]},"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>The objective of the present study was to investigate exposure\u2013response relationships between current endotoxin exposure and allergic and respiratory symptoms in adults, taking into account farming exposures during childhood.<\/jats:p>\n                  <jats:p>A cross-sectional study was conducted among 877 Dutch farmers and agricultural industry workers in 2006. Based on 249 full-shift personal airborne endotoxin samples, a job-exposure matrix was constructed to assign endotoxin exposure levels to all participants. Associations between endotoxin exposure and questionnaire data on symptoms were studied by multiple logistic regression.<\/jats:p>\n                  <jats:p>Adjusted odds ratios (OR) for an interquartile range increase in endotoxin level were elevated for respiratory symptoms such as wheezing (OR 1.41 (95% confidence interval 1.16\u20131.72)), wheezing with shortness of breath (1.50 (1.18\u20131.90)) and daily cough (1.29 (1.03\u20131.62)). In contrast, endotoxin was strongly associated with a decreased prevalence of hay fever (0.62 (0.49\u20130.78)). Workers who had grown up on a farm had a lower prevalence of hay fever, but no evidence was found of effect modification by farm childhood.<\/jats:p>\n                  <jats:p>In conclusion, occupational endotoxin exposure in adulthood is associated with an increased risk of asthma-like symptoms but a reduced prevalence of hay fever.<\/jats:p>","DOI":"10.1183\/09031936.00090607","type":"journal-article","created":{"date-parts":[[2008,2,6]],"date-time":"2008-02-06T20:34:28Z","timestamp":1202330068000},"page":"1241-1248","source":"Crossref","is-referenced-by-count":93,"title":["Exposure\u2013response analysis of allergy and respiratory symptoms in endotoxin-exposed adults"],"prefix":"10.1183","volume":"31","author":[{"given":"L. A. 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