{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:36:52Z","timestamp":1793824612843,"version":"4.6.1"},"reference-count":39,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2008,11,19]]},"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p>The characteristics of patients with rheumatoid arthritis (RA) who develop obliterative bronchiolitis characterised by severe airflow obstruction have been hitherto poorly investigated.<\/jats:p>\n                  <jats:p>\n                    A retrospective study of 25 patients with RA and functional evidence of obliterative bronchiolitis (forced expiratory volume in one second (FEV\n                    <jats:sub>1<\/jats:sub>\n                    )\/forced vital capacity (FVC) &lt;50% and\/or residual volume (RV)\/total lung capacity (TLC) &gt;140% predicted) was conducted.\n                  <\/jats:p>\n                  <jats:p>\n                    Patients (mean\u00b1\n                    <jats:sc>sd<\/jats:sc>\n                    age 64\u00b111\u2005yrs) included 17 never-smokers and eight ex-smokers (10.5\u00b15.4\u2005pack-yrs). The diagnosis of RA preceded respiratory symptoms in 88% of cases. Dyspnoea on exertion was present in all patients and bronchorrhea in 44%. High-resolution computed tomography findings included: bronchial wall thickening (96%), bronchiectasis (40%), mosaic pattern (40%), centrilobular emphysema (56%), and reticular and\/or ground-glass opacities (32%). Pulmonary function tests showed: FEV\n                    <jats:sub>1<\/jats:sub>\n                    41\u00b112% pred, FEV\n                    <jats:sub>1<\/jats:sub>\n                    \/FVC 49\u00b114%, FVC 70\u00b120% pred, RV 148\u00b168% pred and RV\/TLC 142\u00b134% pred. Lung biopsy, available in nine patients, demonstrated constrictive, follicular and mixed bronchiolitis. Patients were followed for 48.2\u00b149\u2005months. Treatment was poorly effective. Chronic respiratory failure occurred in 40% of patients, and four patients died.\n                  <\/jats:p>\n                  <jats:p>Obliterative bronchiolitis associated with rheumatoid arthritis is a severe and under-recognised condition leading to respiratory failure and death in a high proportion of patients.<\/jats:p>","DOI":"10.1183\/09031936.00091608","type":"journal-article","created":{"date-parts":[[2009,1,7]],"date-time":"2009-01-07T20:45:21Z","timestamp":1231361121000},"page":"1053-1061","source":"Crossref","is-referenced-by-count":98,"title":["Characterisation of severe obliterative bronchiolitis in rheumatoid arthritis"],"prefix":"10.1183","volume":"33","author":[{"given":"G.","family":"Devouassoux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Cottin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Liot\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Marchand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Frachon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Schuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"B\u00e9jui-Thivolet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-F.","family":"Cordier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Groupe d'Etudes et de Recherche sur les Maladies \u201cOrphelines\u201d Pulmonaires (GERM\u201cO\u201dP)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2009,1,7]]},"reference":[{"key":"2024102019470556000_33.5.1053.1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740410005845"},{"key":"2024102019470556000_33.5.1053.2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200703-045MS"},{"key":"2024102019470556000_33.5.1053.3","first-page":"427","volume":"46","year":"1977","journal-title":"Q J Med"},{"key":"2024102019470556000_33.5.1053.4","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-985609"},{"key":"2024102019470556000_33.5.1053.5","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1148\/radiology.212.3.r99se04637","volume":"212","year":"1999","journal-title":"Radiology"},{"key":"2024102019470556000_33.5.1053.6","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.5.8912776"},{"key":"2024102019470556000_33.5.1053.7","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1136\/ard.56.10.596","volume":"56","year":"1997","journal-title":"Ann Rheum Dis"},{"key":"2024102019470556000_33.5.1053.8","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.5.9710018"},{"key":"2024102019470556000_33.5.1053.9","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"2024102019470556000_33.5.1053.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.09.001"},{"key":"2024102019470556000_33.5.1053.11","unstructured":"King TE Jr. Bronchiolitis. 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