{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:55:28Z","timestamp":1788864928715,"version":"build-2803163510"},"reference-count":24,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,10,12]]},"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>The need for a less invasive procedure than surgical lung volume reduction that can produce consistent improvements with reduced morbidity remains a medical goal in patients with emphysema. We sought to determine the effect of bronchoscopic thermal vapour ablation (BTVA) on lung volumes and outcomes in patients with emphysema.<\/jats:p><jats:p>44 patients with upper lobe-predominant emphysema were treated unilaterally with BTVA. Entry criteria included: age 40\u201375 yrs, forced expiratory volume in 1 s (FEV<jats:sub>1<\/jats:sub>) 15\u201345% predicted, previous pulmonary rehabilitation and a heterogeneity index (tissue\/air ratio of lower lobe\/upper lobe) from high-resolution computed tomography (HRCT) \u22651.2. Changes in FEV<jats:sub>1<\/jats:sub>, St George's Respiratory Questionnaire (SGRQ), 6-min walk distance (6MWD), modified Medical Research Council (mMRC) dyspnoea score, and hyperinflation were measured at baseline, and 3 and 6 months post-BTVA.<\/jats:p><jats:p>At 6 months, mean\u00b1<jats:sc>se<\/jats:sc>FEV<jats:sub>1<\/jats:sub>improved by 141\u00b126 mL (p&lt;0.001) and residual volume was reduced by 406\u00b1113 mL (p&lt;0.0001). SGRQ total score improved by 14.0\u00b12.4 points (p&lt;0.001), with 73% improving by \u22654 points. Improvements were observed in 6MWD (46.5\u00b110.6 m) and mMRC dyspnoea score (0.9\u00b10.2) (p&lt;0.001 for both). Lower respiratory events (n=11) were the most common adverse event and occurred most often during the initial 30 days.<\/jats:p><jats:p>BTVA therapy results in clinically relevant improvements in lung function, quality of life and exercise tolerance in upper lobe predominant emphysema.<\/jats:p>","DOI":"10.1183\/09031936.00092411","type":"journal-article","created":{"date-parts":[[2011,11,11]],"date-time":"2011-11-11T05:34:32Z","timestamp":1320989672000},"page":"1326-1333","source":"Crossref","is-referenced-by-count":115,"title":["Bronchoscopic thermal vapour ablation therapy in the management of heterogeneous emphysema"],"prefix":"10.1183","volume":"39","author":[{"given":"Gregory","family":"Snell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix J.F.","family":"Herth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley M.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Witt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Gotfried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arschang","family":"Valipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Stanzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim J.","family":"Egan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Kesten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2011,11,10]]},"reference":[{"key":"2024102020550437000_39.6.1326.1","first-page":"789","article-title":"Surgical treatment of pulmonary emphysema","volume":"23","author":"Brantingan","year":"1957","journal-title":"Am Surg"},{"key":"2024102020550437000_39.6.1326.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(95)70426-4"},{"key":"2024102020550437000_39.6.1326.3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.6.1750"},{"key":"2024102020550437000_39.6.1326.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030287"},{"key":"2024102020550437000_39.6.1326.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.05.069"},{"key":"2024102020550437000_39.6.1326.6","unstructured":"National Institutes of Health. 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