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It also contributes to the low adherence to exercise training programmes in sedentary adults and in COPD patients. The mechanisms of dyspnoea are still unclear. Recent studies have emphasised the multidimensional nature of dyspnoea in the sensory\u2013perceptual (intensity and quality), affective distress and impact domains. The perception of dyspnoea involves a complex chain of events that depend on varying cortical integration of several afferent\/efferent signals and coloured by affective processing. This review, which stems from the European Respiratory Society research symposium held in Paris, France in November 2012, aims to provide state-of-the-art advances on the multidimensional and multidisciplinary aspects of dyspnoea, by addressing three different themes: 1) the neurophysiology of dyspnoea, 2) exercise and dyspnoea, and 3) the clinical impact and management of dyspnoea.<\/jats:p>","DOI":"10.1183\/09031936.00092613","type":"journal-article","created":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T08:17:56Z","timestamp":1392365876000},"page":"1750-1762","source":"Crossref","is-referenced-by-count":277,"title":["Dyspnoea: a multidimensional and multidisciplinary 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