{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:44:54Z","timestamp":1791146694225,"version":"4.1.0"},"reference-count":31,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,9,26]]},"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Obstructive sleep apnoea (OSA) is often treated with autotitrating continuous positive airway pressure (autoCPAP) devices. Clinical and bench tests of these devices have suggested performance limitations. These studies do not indicate whether this is a failure to detect or a failure to respond to airway obstruction.<\/jats:p>\n                  <jats:p>In this randomised, crossover trial, 34 patients with moderate-to-severe OSA underwent polysomnography on two laboratory visits. The autoCPAP device was randomly set to a fixed subtherapeutic pressure (detection assessment) or autotitrating mode (response assessment). Airflow was measured both from the autoCPAP (autoCPAP flow) and directly from the nasal mask, and recorded on polysomnography. Apnoea\/hypopnoea indices (AHIs) measured at the two sites and from the autoCPAP download report were compared.<\/jats:p>\n                  <jats:p>\n                    Regarding detection, the AHI measured from the nasal mask showed good agreement with the autoCPAP flow AHI, but agreement was lower with the autoCPAP report AHI. In autotitrating mode, there was significant misclassification of those with and without OSA (AHI \u226510 events\u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) on the autoCPAP report. Regarding response, residual OSA (AHI \u226510 events\u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) was still evident in 24% of patients during autotitration.\n                  <\/jats:p>\n                  <jats:p>In some patients, autoCPAP fails to detect and\/or respond to sleep apnoea. Clinicians should consider limitations of each device and use caution when using autoCPAP report statistics to verify effective treatment.<\/jats:p>","DOI":"10.1183\/09031936.00093811","type":"journal-article","created":{"date-parts":[[2011,11,11]],"date-time":"2011-11-11T00:34:32Z","timestamp":1320971672000},"page":"1391-1397","source":"Crossref","is-referenced-by-count":26,"title":["Residual sleep-disordered breathing during autotitrating continuous positive airway pressure therapy"],"prefix":"10.1183","volume":"39","author":[{"given":"Angela L.","family":"Denotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith K.H.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"George C.","family":"Dungan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Gilholme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel S.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald R.","family":"Grunstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2011,11,10]]},"reference":[{"key":"2024102020550823000_39.6.1391.1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/sleep\/29.3.375","article-title":"Practice parameters for the use of continuous and bilevel positive airway pressure devices to treat adult patients with sleep-related breathing disorders","volume":"29","author":"Kushida","year":"2006","journal-title":"Sleep"},{"issue":"Suppl. 8","key":"2024102020550823000_39.6.1391.2","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1093\/sleep\/16.suppl_8.S120","article-title":"Feasibility of a self-setting CPAP machine","volume":"16","author":"Berthon-Jones","year":"1993","journal-title":"Sleep"},{"issue":"Suppl. 9","key":"2024102020550823000_39.6.1391.3","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1093\/sleep\/19.suppl_9.S131","article-title":"Nasal continuous positive airway pressure treatment: current realities and future","volume":"19","author":"Berthon-Jones","year":"1996","journal-title":"Sleep"},{"key":"2024102020550823000_39.6.1391.4","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1164\/ajrccm.154.3.8810613","article-title":"Automated continuous positive airway pressure titration for obstructive sleep apnea syndrome","volume":"154","author":"Teschler","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102020550823000_39.6.1391.5","first-page":"CD003531","article-title":"Pressure modification for improving usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea","volume":"4","author":"Smith","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"2024102020550823000_39.6.1391.6","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2602"},{"key":"2024102020550823000_39.6.1391.7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1372"},{"key":"2024102020550823000_39.6.1391.8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.5664\/jcsm.27235","article-title":"Autoadjusting positive pressure trial in adults with sleep apnea assessed by a simplified diagnostic approach","volume":"4","author":"Torre-Bouscoulet","year":"2008","journal-title":"J Clin Sleep Med"},{"key":"2024102020550823000_39.6.1391.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2009.05.017"},{"key":"2024102020550823000_39.6.1391.10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/sleep\/31.1.141","article-title":"Practice parameters for the use of autotitrating continuous positive airway pressure devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome: an update for 2007. 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