{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:50:13Z","timestamp":1790729413798,"version":"4.1.0"},"reference-count":34,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,1,7]]},"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>Recent evidence suggests that idiopathic nonspecific interstitial pneumonia (iNSIP) is a distinct clinical entity amongst other idiopathic interstitial pneumonias, and some data seem to suggest a possible pathogenetic role of autoimmunity. The aim of the present study was to assess if iNSIP might represent an early lung manifestation of an autoimmune disease.<\/jats:p>\n                  <jats:p>After initial review of cases found in the medical records database by searching for the term \u201cNSIP\u201d (n = 63), 37 iNSIP cases were identified, and were re-evaluated using a dynamic integrated multidisciplinary approach.<\/jats:p>\n                  <jats:p>\n                    27 cases with iNSIP were selected for the study. Mean\u00b1\n                    <jats:sc>sd<\/jats:sc>\n                    age at first respiratory symptom was 54.2\u00b18 yrs, 70% were females, and 59% were never-smokers. At follow-up (mean\u00b1\n                    <jats:sc>sd<\/jats:sc>\n                    59.7\u00b129 months, range 12\u2013138 months), autoimmune diseases occurred in 14 (52%) patients, with seven (26%) cases of autoimmune thyroiditis, six (22%) of undifferentiated connective tissue disease and three (11%) of connective tissue disease. Patients developing autoimmune diseases were older and more frequently never-smoking females.\n                  <\/jats:p>\n                  <jats:p>In &gt;50% of patients diagnosed with iNSIP, evidence of autoimmune diseases develops within 2 yrs, suggesting a probable link between the clinical entity of iNSIP and autoimmune disorders.<\/jats:p>","DOI":"10.1183\/09031936.00094910","type":"journal-article","created":{"date-parts":[[2011,2,22]],"date-time":"2011-02-22T14:20:53Z","timestamp":1298384453000},"page":"384-391","source":"Crossref","is-referenced-by-count":78,"title":["Idiopathic nonspecific interstitial pneumonia: an interstitial lung disease associated with autoimmune disorders?"],"prefix":"10.1183","volume":"38","author":[{"given":"M.","family":"Romagnoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Nannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Piciucchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Girelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gurioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Casoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ravaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tomassetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ch.","family":"Gurioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Gavelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Carloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dubini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Cantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Chilosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Poletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2011,1,27]]},"reference":[{"key":"2024102020330312000_38.2.384.1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/00000478-199402000-00003","article-title":"Nonspecific interstitial pneumonia\/fibrosis. 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