{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:19:26Z","timestamp":1791289166773,"version":"4.3.0"},"reference-count":30,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2012,9,26]]},"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Intermittent hypoxia, the main stimulus of obstructive sleep apnoea (OSA), induces inflammation, leading to early atherosclerosis. Whether the cyclooxygenase (COX) pathway contributes to intermittent hypoxia-induced atherosclerosis remains to be determined.<\/jats:p><jats:p>We studied the effects of 8-weeks of intermittent hypoxia exposure on COX-pathway gene expression and atherosclerosis, and the influence of COX-1 inhibition by SC-560 on atherosclerosis progression in aortas of apolipoprotein E<jats:sup>-\/-<\/jats:sup>mice. Urinary 11-dehydrothromboxane B<jats:sub>2<\/jats:sub>(11-dTXB<jats:sub>2<\/jats:sub>) was assessed in 50 OSA subjects free of cardiovascular risk factor matched for age and body mass index with 25 controls, and 56 OSA with cardiovascular risk factor.<\/jats:p><jats:p>Intermittent hypoxia significantly increased atherosclerotic lesion sizes, mRNA levels of COX-1 and thromboxane synthase (TXBS). Lesion sizes correlated to COX-1 (r = 0.654, p = 0.0003) and TXBS (r = 0.693, p&lt;0.0001) mRNA levels. COX-1 inhibition reduced lesion progression in intermittent hypoxia mice only (p = 0.04). Urinary 11-dTXB<jats:sub>2<\/jats:sub>was similar in OSA subjects free of cardiovascular risk factor and controls, but was increased by 13% (p = 0.007) in OSA subjects with cardiovascular risk factor compared with those without.<\/jats:p><jats:p>Although OSA itself was not associated with increased urinary 11-dTXB<jats:sub>2<\/jats:sub>concentration, the COX-1 pathway was activated in intermittent hypoxia-exposed mice and in OSA subjects presenting with cardiovascular risk factor, and may contribute to intermittent hypoxia-induced atherogenesis. COX-1 inhibition could be of clinical interest in the prevention of cardiovascular morbidity in OSA.<\/jats:p>","DOI":"10.1183\/09031936.00096512","type":"journal-article","created":{"date-parts":[[2012,10,13]],"date-time":"2012-10-13T00:52:14Z","timestamp":1350089534000},"page":"404-413","source":"Crossref","is-referenced-by-count":49,"title":["Intermittent hypoxia-activated cyclooxygenase pathway: role in 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