{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:32:18Z","timestamp":1791318738571,"version":"4.3.1"},"reference-count":32,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,11,7]]},"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>\n                    Pulmonary veno-occlusive disease (PVOD), a rare form of pulmonary arterial hypertension (PAH), requires histological proof for definitive diagnosis; however, lung biopsy is not recommended in PAH. Recent conjoint European Respiratory Society\/European Society of Cardiology guidelines suggest that nonmatched perfusion defects on ventilation\/perfusion (\n                    <jats:italic>V<\/jats:italic>\n                    \u2032\/\n                    <jats:italic>Q<\/jats:italic>\n                    \u2032) lung scanning in PAH patients may suggest PVOD. The aim of our study was to evaluate\n                    <jats:italic>V<\/jats:italic>\n                    \u2032\/\n                    <jats:italic>Q<\/jats:italic>\n                    \u2032 lung scans in a large cohort of PVOD and idiopathic or heritable PAH patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>V<\/jats:italic>\n                    \u2032\/\n                    <jats:italic>Q<\/jats:italic>\n                    \u2032 lung scans from 70 patients with idiopathic or heritable PAH and 56 patients with confirmed or highly probable PVOD were reviewed in a double-blind manner.\n                  <\/jats:p>\n                  <jats:p>\n                    The vast majority of\n                    <jats:italic>V<\/jats:italic>\n                    \u2032\/\n                    <jats:italic>Q<\/jats:italic>\n                    \u2032 lung scans were normal or without significant abnormalities in both groups. No differences in ventilation or perfusion lung scans were observed between PAH and PVOD patients (all p&gt;0.05). Furthermore, no differences were observed between confirmed (n=31) or highly probable PVOD (n=25). Nonmatched perfusion defects were found in seven (10%) idiopathic PAH patients and four (7.1%) PVOD patients (p&gt;0.05).\n                  <\/jats:p>\n                  <jats:p>\n                    Nonmatched perfusion defects were rarely seen in a large cohort of idiopathic or heritable PAH and PVOD patients. Future recommendations should be amended according to these results suggesting that\n                    <jats:italic>V<\/jats:italic>\n                    \u2032\/\n                    <jats:italic>Q<\/jats:italic>\n                    \u2032 lung scanning is not useful in discriminating PVOD from idiopathic PAH.\n                  <\/jats:p>","DOI":"10.1183\/09031936.00097911","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T07:23:48Z","timestamp":1321514628000},"page":"75-83","source":"Crossref","is-referenced-by-count":65,"title":["Ventilation\/perfusion lung scan in pulmonary veno-occlusive 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