{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:54:19Z","timestamp":1780584859068,"version":"3.54.1"},"reference-count":21,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,11,20]]},"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Obstructive sleep apnoea (OSA) is an independent risk factor for hypertension. Increased angiotensin-converting enzyme (ACE) activity may be a possible promoting mechanism with different ACE insertion\/deletion (I\/D) genotypes influencing this activity. Studies investigating the association of ACE I\/D polymorphisms with OSA have shown conflicting results. We aimed to undertake a meta-analysis of existing studies exploring the association of ACE I\/D polymorphisms with the risk of OSA and hypertension.<\/jats:p><jats:p>10 studies were included in a random effects meta-analysis, comprising 1,227 OSA subjects and 1,227 controls.<\/jats:p><jats:p>The effect size was measured using the odds ratio. The risk of having OSA in carriers of the D allele was 0.92 (95% CI 0.69\u20131.23). There was statistically significant heterogeneity across the studies (I<jats:sup>2<\/jats:sup>=42%, p=0.08 and I<jats:sup>2<\/jats:sup>=74%, p&lt;0.0001 for genotype and allele frequency, respectively). The association of D allele frequency with the risk of OSA remained nonsignificant after stratification based on ethnicity, source of population sample, and the presence of hypertension. Subgroup analysis failed to show any influence of genotype and allele frequency on OSA severity.<\/jats:p><jats:p>This meta-analysis revealed no association between the ACE I\/D polymorphisms and OSA susceptibility.<\/jats:p>","DOI":"10.1183\/09031936.00100211","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T02:17:47Z","timestamp":1324347467000},"page":"394-399","source":"Crossref","is-referenced-by-count":8,"title":["The association of angiotensin-converting enzyme gene insertion\/deletion polymorphisms with OSA: a meta-analysis"],"prefix":"10.1183","volume":"40","author":[{"given":"Peilin","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil J.","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata L.","family":"Riha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2011,12,19]]},"reference":[{"key":"2024102020570362000_40.2.394.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71141-7"},{"key":"2024102020570362000_40.2.394.2","first-page":"325","article-title":"Serum angiotensin converting enzyme and the obstructive sleep apnea hypopnea syndrome","volume":"4","author":"Benjamin","year":"2008","journal-title":"J Clin Sleep Med"},{"key":"2024102020570362000_40.2.394.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07445-7"},{"key":"2024102020570362000_40.2.394.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00086608"},{"key":"2024102020570362000_40.2.394.5","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000223145.74217.e7"},{"key":"2024102020570362000_40.2.394.6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200405-616OC"},{"key":"2024102020570362000_40.2.394.7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114844"},{"key":"2024102020570362000_40.2.394.8","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2003.71"},{"key":"2024102020570362000_40.2.394.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2005.02.009"},{"key":"2024102020570362000_40.2.394.10","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199715120-00059"},{"key":"2024102020570362000_40.2.394.11","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.2.484"},{"key":"2024102020570362000_40.2.394.12","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.17407280"},{"key":"2024102020570362000_40.2.394.13","doi-asserted-by":"publisher","DOI":"10.4238\/vol9-2gmr755"},{"key":"2024102020570362000_40.2.394.14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1291\/hypres.23.407","article-title":"Angiotensin-converting enzyme gene insertion\/deletion (I\/D) polymorphism in hypertensive patients with different degrees of obstructive sleep apnea","volume":"23","author":"Zhang","year":"2000","journal-title":"Hypertens Res"},{"key":"2024102020570362000_40.2.394.15","first-page":"456","article-title":"[Study on the polymorphism of angiotensin converting enzyme genes and serum angiotensin II level in patients with obstructive sleep apnea hypopnea syndrome accompanied hypertension]","volume":"18","author":"Li","year":"2004","journal-title":"Lin Chuang Er Bi Yan Hou Ke Za Zhi"},{"key":"2024102020570362000_40.2.394.16","first-page":"507","article-title":"[Association of polymorphisms in the angiotensin system genes with obstructive sleep apnea-hypopnea syndrome]","volume":"27","author":"Zhang","year":"2004","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"2024102020570362000_40.2.394.17","unstructured":"Higgins JPT Green S , eds. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. Oxford, The Cochrane Collaboration, 2011."},{"key":"2024102020570362000_40.2.394.18","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1097\/HJH.0b013e328017f6d5","article-title":"Interaction between the angiotensin-converting enzyme gene insertion\/deletion polymorphism and obstructive sleep apnoea as a mechanism for hypertension","volume":"25","author":"Bostr\u00f6m","year":"2007","journal-title":"J Hypertens"},{"key":"2024102020570362000_40.2.394.19","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-010-9335-2"},{"key":"2024102020570362000_40.2.394.20","first-page":"489","article-title":"[Angiotension I converting enzyme gene polymorphism in Chinese patients with obstructive sleep apnea syndrome]","volume":"21","author":"Xiao","year":"1998","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"2024102020570362000_40.2.394.21","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1093\/sleep\/32.11.1507","article-title":"H Lack of association of the APOE epsilon 4 allele with the risk of obstructive sleep apnea: meta-analysis and meta-regression","volume":"32","author":"Thakre","year":"2009","journal-title":"Sleep"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00100211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:34:29Z","timestamp":1740378869000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00100211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,19]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,7,31]]},"published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1183\/09031936.00100211"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00100211","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,19]]}}}