{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:46:50Z","timestamp":1792007210497,"version":"4.4.0"},"reference-count":28,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2010,9,16]]},"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>The aims of this study were to assess the prevalence of iron deficiency in idiopathic pulmonary arterial hypertension (IPAH) and investigate whether oral iron supplementation has effects in iron-deficient patients.<\/jats:p>\n                  <jats:p>Iron parameters were measure for all IPAH patients attending our centre (VU University Medical Center, Amsterdam, the Netherlands) between May 2009 and February 2010. Iron data were related to clinical parameters, including 6-min walking distance (6MWD), and haemodynamic parameters measured during right heart catheterisation. In a subset of iron-deficient patients, the uptake of iron from the bowel was studied after administering oral iron for 4 weeks.<\/jats:p>\n                  <jats:p>\n                    Iron deficiency was found in 30 (43%) out of 70 patients. 6MWD was reduced in iron-deficient patients compared with iron-sufficient patients (mean\u00b1\n                    <jats:sc>sd<\/jats:sc>\n                    390\u00b1138\n                    <jats:italic>versus<\/jats:italic>\n                    460\u00b1143 m; p&lt;0.05) irrespective of the existence of anaemia. In a subset of 18 patients that received oral iron, ferritin levels were significantly increased, although eight patients only slightly increased their iron storage.\n                  <\/jats:p>\n                  <jats:p>This study shows that iron deficiency is frequently present in IPAH and is associated with a lower exercise capacity. The small response to oral iron in 44% of the treated patients suggests impaired iron absorption in these patients.<\/jats:p>","DOI":"10.1183\/09031936.00100510","type":"journal-article","created":{"date-parts":[[2010,9,30]],"date-time":"2010-09-30T21:11:38Z","timestamp":1285881098000},"page":"1386-1391","source":"Crossref","is-referenced-by-count":178,"title":["Iron deficiency is common in idiopathic pulmonary arterial hypertension"],"prefix":"10.1183","volume":"37","author":[{"given":"G.","family":"Ruiter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lankhorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Boonstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.E.","family":"Postmus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zweegman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Westerhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.J.","family":"van der Laarse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vonk-Noordegraaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2010,9,30]]},"reference":[{"key":"2024102020273351000_37.6.1386.1","first-page":"E418","article-title":"Muscle mitochondrial bioenergetics, oxygen supply, and work capacity during dietary iron deficiency and repletion","volume":"242","author":"Davies","year":"1982","journal-title":"Am J Physiol"},{"key":"2024102020273351000_37.6.1386.2","first-page":"E535","article-title":"Distinguishing effects of anaemia and muscle iron deficiency on exercise bioenergetics in the rat","volume":"246","author":"Davies","year":"1984","journal-title":"Am J Physiol"},{"key":"2024102020273351000_37.6.1386.3","doi-asserted-by":"crossref","first-page":"568S","DOI":"10.1093\/jn\/131.2.568S","volume":"131","author":"Beard","year":"2001","journal-title":"J Nutr"},{"key":"2024102020273351000_37.6.1386.4","doi-asserted-by":"crossref","first-page":"676S","DOI":"10.1093\/jn\/131.2.676S","article-title":"Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship","volume":"131","author":"Haas","year":"2001","journal-title":"J Nutr"},{"key":"2024102020273351000_37.6.1386.5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/ajcn\/79.3.437","article-title":"Tissue iron deficiency without anaemia impairs adaptation in endurance capacity after aerobic training in previously untrained females","volume":"79","author":"Brownlie","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"2024102020273351000_37.6.1386.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.015"},{"key":"2024102020273351000_37.6.1386.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.07.029"},{"key":"2024102020273351000_37.6.1386.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.036"},{"key":"2024102020273351000_37.6.1386.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908355"},{"key":"2024102020273351000_37.6.1386.10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-027631"},{"key":"2024102020273351000_37.6.1386.11","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-008-9086-x"},{"key":"2024102020273351000_37.6.1386.12","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0655"},{"key":"2024102020273351000_37.6.1386.13","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.12.030"},{"key":"2024102020273351000_37.6.1386.14","unstructured":"Krasuski R Hart S Smith B . 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