{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:02:52Z","timestamp":1791302572519,"version":"4.1.0"},"reference-count":38,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2013,2,12]]},"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>The aim of the study was to characterise gastro-oesophageal reflux (GOR) in idiopathic pulmonary fibrosis (IPF).<\/jats:p>\n                  <jats:p>40 consecutive IPF patients underwent pulmonary high-resolution computed tomography (HRCT) scan and impedance-pH monitoring while off antisecretory therapy. The presence of pulmonary fibrosis was assessed using validated HRCT scores. Reflux features included distal oesophageal acid exposure, number of acid\/weakly acidic reflux episodes and their proximal migration. 40 consecutive patients with interstitial lung disease other than IPF (non-IPF patients) and 50 healthy volunteers were also enrolled.<\/jats:p>\n                  <jats:p>\n                    IPF patients had significantly higher (p&lt;0.01) oesophageal acid exposure (median (interquartile range (IQR)) 9.25 (4.7\u201315.4)%\n                    <jats:italic>versus<\/jats:italic>\n                    3.3 (1.4\u20137.4)%\n                    <jats:italic>versus<\/jats:italic>\n                    0.7 (0.2\u20134.2)%, number of acid (median (IQR) 45 (23\u201355)\n                    <jats:italic>versus<\/jats:italic>\n                    32 (19\u201344)\n                    <jats:italic>versus<\/jats:italic>\n                    18 (10\u201331)), weakly acidic (median (IQR) 34 (19\u201343)\n                    <jats:italic>versus<\/jats:italic>\n                    21 (11\u201333)\n                    <jats:italic>versus<\/jats:italic>\n                    18 (15\u201328)) and proximal reflux (median (IQR) 51 (26.5\u201365.5)\n                    <jats:italic>versus<\/jats:italic>\n                    20 (9.5\u201334.5)\n                    <jats:italic>versus<\/jats:italic>\n                    9 (5\u201320)) events compared to non-IPF patients and healthy volunteers, respectively. Pulmonary fibrosis HRCT scores correlated well with reflux episodes in both the distal (r\n                    <jats:sup>2<\/jats:sup>\n                    =0.567) and proximal (r\n                    <jats:sup>2<\/jats:sup>\n                    =0.6323) oesophagus. Patients with IPF had more bile acids and pepsin (p&lt;0.03) in bronchoalveolar lavage fluid (BALF) (62% and 67%, respectively) and saliva (61% and 68%, respectively) than non-IPF patients (25% and 25% in BALF, and 33% and 36%, respectively, in saliva) and controls (0% and 0% in BALF and saliva, respectively).\n                  <\/jats:p>\n                  <jats:p>Acid GOR is common in IPF, but weakly acidic GOR may also occur. Patients with IPF had a risk of pulmonary aspiration of gastric contents. Outcome studies with intense antireflux therapy are needed.<\/jats:p>","DOI":"10.1183\/09031936.00101212","type":"journal-article","created":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:21:45Z","timestamp":1362702105000},"page":"1322-1331","source":"Crossref","is-referenced-by-count":212,"title":["Gastro-oesophageal reflux and gastric aspiration in idiopathic pulmonary fibrosis patients"],"prefix":"10.1183","volume":"42","author":[{"given":"Edoardo","family":"Savarino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Marabotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuele","family":"Furnari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Sconfienza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Ghio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Zentilin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Savarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"2024102021355357000_42.5.1322.1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.ats3-00"},{"key":"2024102021355357000_42.5.1322.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00847-6"},{"key":"2024102021355357000_42.5.1322.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200808-1359OC"},{"key":"2024102021355357000_42.5.1322.4","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.6.9804105"},{"key":"2024102021355357000_42.5.1322.5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00037005"},{"key":"2024102021355357000_42.5.1322.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.09.085"},{"key":"2024102021355357000_42.5.1322.7","first-page":"122","article-title":"Experimental aspiration pneumonia. 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