{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:57:17Z","timestamp":1790683037169,"version":"4.1.0"},"reference-count":54,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,9,7]]},"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>We aimed to evaluate the effect of the Mediterranean diet (MD) compared with a prudent diet (PD) combined with physical activity on obese obstructive sleep apnoea syndrome (OSAS) patients who were treated with continuous positive airway pressure.<\/jats:p><jats:p>900 patients were evaluated and 40 obese patients (body mass index \u226530.0 kg\u00b7m<jats:sup>\u22122<\/jats:sup>) who met the inclusion criteria, with moderate-to-severe OSAS (apnoea\u2013hypopnoea index (AHI) &gt;15 events\u00b7h<jats:sup>\u22121<\/jats:sup>and Epworth Sleepiness Scale score &gt;10) based on overnight attended polysomnography, were included in the study. After randomisation, 20 patients followed the MD and 20 a PD for a 6-month period. All patients were counselled to increase their physical activity.<\/jats:p><jats:p>Concerning sleep parameters, only AHI during rapid eye movement (REM) sleep was reduced to a statistically significant degree, by mean\u00b1<jats:sc>sd<\/jats:sc>18.4\u00b117.6 events\u00b7h<jats:sup>\u22121<\/jats:sup>in the MD group and by 2.6\u00b123.7 events\u00b7h<jats:sup>\u22121<\/jats:sup>in the PD group (p&lt;0.05). The MD group also showed a greater reduction in waist circumference (WC) (-8.7\u00b13.6 cm), WC\/height ratio (-0.04\u00b10.02 cm\u00b7m<jats:sup>\u22121<\/jats:sup>) and WC\/hip ratio (-0.04\u00b10.03 cm\u00b7cm<jats:sup>\u22121<\/jats:sup>), compared with the other group (-2.6\u00b11.7 events\u00b7h<jats:sup>\u22121<\/jats:sup>, -5.7\u00b13.8 cm, -0.03\u00b10.02 cm\u00b7m<jats:sup>\u22121<\/jats:sup>and 0.02\u00b10.02 cm\u00b7cm<jats:sup>\u22121<\/jats:sup>, respectively; p&lt;0.05).<\/jats:p><jats:p>Our results showed that the MD combined with physical activity for a 6-month period was effective in reducing the AHI during REM sleep without any statistically significant effect in the other sleep parameters, compared with a PD in obese adults with moderate-to-severe OSAS.<\/jats:p>","DOI":"10.1183\/09031936.00103411","type":"journal-article","created":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T00:55:54Z","timestamp":1319763354000},"page":"1398-1404","source":"Crossref","is-referenced-by-count":56,"title":["Effect of Mediterranean diet<i>versus<\/i>prudent diet combined with physical activity on OSAS: a randomised trial"],"prefix":"10.1183","volume":"39","author":[{"given":"Christopher","family":"Papandreou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia E.","family":"Schiza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izolde","family":"Bouloukaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos M.","family":"Hatzis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony G.","family":"Kafatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos M.","family":"Siafakas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos E.","family":"Tzanakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2011,10,27]]},"reference":[{"key":"2024102020543207000_39.6.1398.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"2024102020543207000_39.6.1398.2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900506"},{"key":"2024102020543207000_39.6.1398.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71141-7"},{"key":"2024102020543207000_39.6.1398.4","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.116"},{"key":"2024102020543207000_39.6.1398.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2010.02.012"},{"key":"2024102020543207000_39.6.1398.6","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-864209"},{"key":"2024102020543207000_39.6.1398.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10532-9"},{"key":"2024102020543207000_39.6.1398.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2009.07.001"},{"key":"2024102020543207000_39.6.1398.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2003.07.007"},{"key":"2024102020543207000_39.6.1398.10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1046\/j.1365-2281.1998.00114.x","article-title":"The effect of a very low-calorie diet-induced weight loss on the severity of obstructive sleep apnoea and autonomic nervous function in obese patients with obstructive sleep apnoea syndrome","volume":"4","author":"Kansanen","year":"1998","journal-title":"Clin Physiol"},{"key":"2024102020543207000_39.6.1398.11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4609"},{"key":"2024102020543207000_39.6.1398.12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200805-669OC"},{"key":"2024102020543207000_39.6.1398.13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.5664\/jcsm.27594","article-title":"A diet and exercise program to improve clinical outcomes in patients with obstructive sleep apnea \u2013 a feasibility study","volume":"5","author":"Barnes","year":"2009","journal-title":"J Clin Sleep Med"},{"key":"2024102020543207000_39.6.1398.14","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1093\/sleep\/29.8.1036","article-title":"Medical therapy for obstructive sleep apnea: a review by the Medical Therapy for Obstructive Sleep Apnea Task Force of the Standards of Practice Committee of the American Academy of Sleep Medicine","volume":"29","author":"Veasey","year":"2006","journal-title":"Sleep"},{"key":"2024102020543207000_39.6.1398.15","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph7041720"},{"key":"2024102020543207000_39.6.1398.16","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0726"},{"key":"2024102020543207000_39.6.1398.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2006.05.006"},{"key":"2024102020543207000_39.6.1398.18","unstructured":"Rechtschaffen A Kales A eds. 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