{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:13:07Z","timestamp":1792116787458,"version":"4.4.0"},"reference-count":50,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2007,12,11]]},"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p><jats:italic>Moraxella catarrhalis<\/jats:italic>is a major cause of infectious exacerbations of chronic obstructive lung disease. In pulmonary epithelial cells,<jats:italic>M. catarrhalis<\/jats:italic>induces release of the pro-inflammatory cytokine interleukin (IL)-8, which plays a pivotal role in orchestrating airway inflammation.<\/jats:p><jats:p>The present study demonstrated that protein kinase (PK)C was activated by Moraxella infection and positively regulated<jats:italic>M. catarrhalis<\/jats:italic>-triggered nuclear factor (NF)-\u03baB activation and subsequent IL-8 release. Activation of the PKC\/NF-\u03baB signalling pathway was found to be dependent on expression of the Moraxella-specific ubiquitous surface protein A2. In addition, it was shown that specific isoforms of PKC play differential roles in the fine-tuning of the<jats:italic>M. catarrhalis<\/jats:italic>-induced NF-\u03baB-dependent gene expression through controlling<jats:italic>il8<\/jats:italic>promoter activity. Inhibition of PKC\u03b1 and \u03f5 with chemical inhibitors or using short interfering RNA-mediated gene silencing significantly suppressed, whereas inhibition of PKC<jats:italic>\u03b8<\/jats:italic>increased, the<jats:italic>M. catarrhalis<\/jats:italic>-induced IL-8 transcription and cytokine release.<\/jats:p><jats:p>In conclusion, it was shown that<jats:italic>Moraxella catarrhalis<\/jats:italic>infection activates protein kinase C and its isoforms \u03b1, \u03f5 and<jats:italic>\u03b8<\/jats:italic>, which differentially regulate interleukin-8 transcription in human pulmonary epithelial cells.<\/jats:p>","DOI":"10.1183\/09031936.00103507","type":"journal-article","created":{"date-parts":[[2008,1,10]],"date-time":"2008-01-10T01:34:38Z","timestamp":1199928878000},"page":"725-735","source":"Crossref","is-referenced-by-count":16,"title":["Differential regulation of<i>Moraxella catarrhalis<\/i>-induced interleukin-8 response by protein kinase C isoforms"],"prefix":"10.1183","volume":"31","author":[{"given":"H.","family":"Slevogt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Maqami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Vardarowa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Beermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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