{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:22:59Z","timestamp":1774124579023,"version":"3.50.1"},"reference-count":22,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2009,11,3]]},"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p>This report summarises phase 2 trial results of biologic lung volume reduction (BioLVR) for treatment of advanced homogeneous emphysema.<\/jats:p><jats:p>BioLVR therapy was administered bronchoscopically to 25 patients with homogeneous emphysema in an open-labelled study. Eight patients received low dose (LD) treatment with 10 mL per site at eight subsegments; 17 received high dose (HD) treatment with 20 mL per site at eight subsegments. Safety was assessed in terms of medical complications during 6-month follow-up. Efficacy was assessed in terms of change from baseline in gas trapping, spirometry, diffusing capacity, exercise capacity, dyspnoea and health-related quality of life.<\/jats:p><jats:p>There were no deaths or serious medical complications during the study. A statistically significant reduction in gas trapping was observed at 3-month follow-up among HD patients, but not LD patients. At 6 months, changes from baseline in forced expiratory volume in 1 s (-8.0\u00b113.93%<jats:italic>versus<\/jats:italic>+13.8\u00b120.26%), forced vital capacity (-3.9\u00b19.41%<jats:italic>versus<\/jats:italic>+9.0\u00b113.01%), residual volume\/total lung capacity ratio (-1.4\u00b113.82%<jats:italic>versus<\/jats:italic>-5.4\u00b112.14%), dyspnoea scores (-0.4\u00b11.27<jats:italic>versus<\/jats:italic>-0.8\u00b10.73 units) and St George's Respiratory Questionnaire total domain scores (-4.9\u00b18.3 U<jats:italic>versus<\/jats:italic>-12.2\u00b112.38 units) were better with HD than with LD therapy.<\/jats:p><jats:p>BioLVR therapy with 20 mL per site at eight subsegmental sites may be a safe and effective therapy in patients with advanced homogeneous emphysema.<\/jats:p>","DOI":"10.1183\/09031936.00106009","type":"journal-article","created":{"date-parts":[[2009,11,20]],"date-time":"2009-11-20T02:58:05Z","timestamp":1258685885000},"page":"20-27","source":"Crossref","is-referenced-by-count":59,"title":["Biologic lung volume reduction therapy for advanced homogeneous emphysema"],"prefix":"10.1183","volume":"36","author":[{"given":"Y.","family":"Refaely","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Dransfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.R.","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gotfried","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Leeds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Mclennan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tewari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Krasna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.J.","family":"Criner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2009,11,19]]},"reference":[{"key":"2024102020074865000_36.1.20.1","doi-asserted-by":"publisher","DOI":"10.1007\/s005950050595"},{"key":"2024102020074865000_36.1.20.2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200707-087ET"},{"key":"2024102020074865000_36.1.20.3","doi-asserted-by":"publisher","DOI":"10.1007\/s002680020023"},{"key":"2024102020074865000_36.1.20.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030287"},{"key":"2024102020074865000_36.1.20.5","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-3359(03)00100-5"},{"key":"2024102020074865000_36.1.20.6","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-869537"},{"key":"2024102020074865000_36.1.20.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa030448"},{"key":"2024102020074865000_36.1.20.8","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200801-013ET"},{"key":"2024102020074865000_36.1.20.9","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200810-1639OC"},{"key":"2024102020074865000_36.1.20.10","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200208-842OC"},{"key":"2024102020074865000_36.1.20.11","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200707-085ET"},{"key":"2024102020074865000_36.1.20.12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa11798"},{"key":"2024102020074865000_36.1.20.13","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035005"},{"key":"2024102020074865000_36.1.20.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2007.01117.x"},{"key":"2024102020074865000_36.1.20.15","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"2024102020074865000_36.1.20.16","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1164\/ajrccm.167.9.950","article-title":"ATS statement on six-minute walk test","volume":"167","author":"Brooks","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102020074865000_36.1.20.17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/15412550802093025","article-title":"Computed tomographic-based quantification of emphysema and correlation to pulmonary function and mechanics","volume":"5","author":"Washko","year":"2008","journal-title":"COPD"},{"key":"2024102020074865000_36.1.20.18","doi-asserted-by":"crossref","unstructured":"Kohl G . 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