{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:42:08Z","timestamp":1769276528461,"version":"3.49.0"},"reference-count":26,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2009,12,22]]},"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>CC chemokine receptor 5 (CCR5) is expressed on type-1 T-helper cells, which are involved in the pathogenesis of the granulomatous lung disease chronic beryllium disease (CBD). CCR5 gene (<jats:italic>CCR5<\/jats:italic>) polymorphisms are associated with sarcoidosis severity. The present study explores associations between<jats:italic>CCR5<\/jats:italic>polymorphisms and CBD and its disease progression.<\/jats:p><jats:p>Eight<jats:italic>CCR5<\/jats:italic>polymorphisms were genotyped in CBD (n = 88), beryllium sensitisation (BeS; n = 86) and beryllium-exposed nondiseased controls (n = 173) using PCR with sequence-specific primers. Pulmonary function and bronchoalveolar lavage data were examined for associations with genotypes.<\/jats:p><jats:p>There were no significant differences in genotype and allele frequency between CBD, BeS individuals and controls. In CBD, associations were found with decline in forced expiratory volume in 1 s and forced vital capacity and the<jats:italic>CCR5<\/jats:italic>-3458 thymidine (T)T genotype (p&lt;0.0001), and an increase in alveolar\u2013arterial oxygen tension difference at rest (p = 0.003) and at maximum exercise (p = 0.01) and the -5663 adenine allele. Increased bronchoalveolar lavage lymphocyte numbers were associated with<jats:italic>CCR5<\/jats:italic>-2459 guanine\/-2135T (p = 0.01) only in the combined CBD and BeS group.<\/jats:p><jats:p>This is the first study showing that<jats:italic>CCR5<\/jats:italic>polymorphisms are associated with worsening pulmonary function over time in CBD, suggesting that<jats:italic>CCR5<\/jats:italic>is important in the progression of pulmonary function in CBD. Further studies would be useful to clarify the mechanism whereby CCR5 polymorphisms affect progression of CBD.<\/jats:p>","DOI":"10.1183\/09031936.00107809","type":"journal-article","created":{"date-parts":[[2010,1,15]],"date-time":"2010-01-15T01:33:26Z","timestamp":1263519206000},"page":"331-338","source":"Crossref","is-referenced-by-count":15,"title":["CC chemokine receptor 5 gene polymorphisms in beryllium 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