{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:43:48Z","timestamp":1771472628973,"version":"3.50.1"},"reference-count":26,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2009,10,18]]},"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p>A clinicoradiological presentation of thoracic sarcoidosis requires histopathology in order to establish the diagnosis. Flexible bronchoscopy has a reasonable diagnostic yield and is the procedure of first choice for diagnosis. Endoscopic ultrasound (endoscopic ultrasound-guided fine needle aspiration\/endobronchial ultrasound-guided transbronchial needle aspiration) can help in the diagnosis of sarcoidosis.<\/jats:p><jats:p>An implementation strategy of endoscopic ultrasound for the diagnosis of sarcoidosis following negative flexible bronchoscopy results was examined prospectively in 15 clinics.<\/jats:p><jats:p>A total of 137 patients (92 males; median age 43\u2005yrs) were included, and sarcoidosis was found in 115 (84%). Alternative diagnoses were tuberculosis, lymphangitis carcinomatosa, pneumoconiosis and alveolitis. All patients were sent for flexible bronchoscopy, which was performed in 121 (88%), resulting in a definite diagnosis in 57 (42%). A total of 80 patients were sent for endoscopic ultrasound, which could be performed in 72 (90%), yielding a definite diagnosis in 47 (59%). Endoscopic ultrasound following negative flexible bronchoscopy avoided a surgical procedure in 47 out of 80 patients. The sensitivity of flexible bronchoscopy for sarcoidosis was 45% (95% confidence interval 35\u201354%), but 62% (50\u201372%) if biopsy specimens were taken. The sensitivity of endoscopic ultrasound following negative flexible bronchoscopy results was 71% (58\u201382%). With this strategy, 97 out of 115 (84% (76\u201390%)) of proven sarcoidosis was diagnosed using endoscopy.<\/jats:p><jats:p>This large prospective implementation study (trial number<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT00888212\">NCT00888212<\/jats:ext-link>; ClinicalTrials.gov) shows that endoscopic ultrasound is valuable for diagnosing sarcoidosis after negative flexible bronchoscopy results.<\/jats:p>","DOI":"10.1183\/09031936.00111509","type":"journal-article","created":{"date-parts":[[2009,11,7]],"date-time":"2009-11-07T02:18:23Z","timestamp":1257560303000},"page":"1329-1335","source":"Crossref","is-referenced-by-count":58,"title":["The value of endoscopic ultrasound after bronchoscopy to diagnose thoracic sarcoidosis"],"prefix":"10.1183","volume":"35","author":[{"given":"K. 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