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Specificities, and negative (NPV) and positive (PPV) predictive values of interferon-\u03b3 release assays (IGRAs) and the TST, and the exposure gradient influences on test results among bacille Calmette\u2013Gu\u00e9rin (BCG) vaccinees were evaluated.<\/jats:p><jats:p>Specificity of IGRAs varied 98\u2013100%. In immunocompetent adults, NPV for progression to tuberculosis within 2 yrs were 97.8% for T-SPOT\u00ae.<jats:italic>TB<\/jats:italic>and 99.8% for QFT-G-IT. When test performance of an immunodiagnostic test was not restricted to prior positivity of another test, progression rates to tuberculosis among IGRA-positive individuals followed for 19\u201324 months varied 8\u201315%, exceeding those reported for the TST (2\u20133%). 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