{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:44:31Z","timestamp":1791330271192,"version":"4.3.1"},"reference-count":23,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2014,2,14]]},"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>Some recent studies have shown an association between sleep disordered breathing (SDB) and cancer mortality and incidence but no study has focused on a specific type of cancer. The objective of this study was to analyse the relationship between the severity of SDB and factors related to cutaneous malignant melanoma (CMM) aggressiveness.<\/jats:p><jats:p>We performed a multicentre observational study in 82 consecutive patients diagnosed with CMM. 56 patients in whom melanoma measurements were available were finally included in the study. Melanoma measurements of aggressiveness included: tumour mitotic rate, Breslow index, presence of ulceration, stage of disease and growth rate of melanoma. A sleep study was performed in all the included patients. Multivariate analyses were used to examine the independent relationship between SDB severity (apnoea\u2013hypopnea index (AHI) and nocturnal oxygen desaturation indexes (ODI<jats:sub>3%<\/jats:sub>and ODI<jats:sub>4%<\/jats:sub>)) and measures of CMM aggressiveness.<\/jats:p><jats:p>60.7% of patients had SDB (AHI \u22655) and 14.3% severe obstructive sleep apnoea (AHI \u226530). In fully adjusted multivariate analyses, AHI (OR 1.08, 95% CI 1.02\u20131.14), ODI<jats:sub>3%<\/jats:sub>(OR 1.08, 95% CI 1.02\u20131.11) and ODI<jats:sub>4%<\/jats:sub>(OR 1.1, 95% CI 1.02\u20131.2) were independently associated with an increased melanoma growth rate. Furthermore, AHI, ODI<jats:sub>4%<\/jats:sub>and ODI<jats:sub>3%<\/jats:sub>were significantly correlated with other aggressiveness factors of CMM, such as Breslow index, presence of ulceration and mitotic index.<\/jats:p><jats:p>SDB severity markers are associated with some aggressiveness markers of CMM.<\/jats:p>","DOI":"10.1183\/09031936.00115413","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:18:27Z","timestamp":1395620307000},"page":"1661-1668","source":"Crossref","is-referenced-by-count":96,"title":["Association between sleep disordered breathing and aggressiveness markers of malignant cutaneous melanoma"],"prefix":"10.1183","volume":"43","author":[{"given":"Miguel-\u00c1ngel","family":"Mart\u00ednez-Garc\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Martorell-Calatayud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Nagore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Valero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jose","family":"Selma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eusebi","family":"Chiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Landete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep-Maria","family":"Montserrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Carrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"P\u00e9rez-Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Campos-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Farr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2014,3,23]]},"reference":[{"key":"2024102022401982000_43.6.1661.1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.arbres.2011.01.001","article-title":"Diagnosis and treatment of sleep apnea-hypopnea syndrome. 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