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Bronchiectasis represents the final common pathway of a number of infectious, genetic, autoimmune, developmental and allergic disorders and is highly heterogeneous in its aetiology, impact and prognosis.<\/jats:p><jats:p>The goals of therapy should be: to improve airway mucus clearance through physiotherapy with or without adjunctive therapies; to suppress, eradicate and prevent airway bacterial colonisation; to reduce airway inflammation; and to improve physical functioning and quality of life.<\/jats:p><jats:p>Fortunately, an increasing body of evidence supports interventions in bronchiectasis. The field has benefited greatly from the introduction of evidence-based guidelines in some European countries and randomised controlled trials have now demonstrated the benefit of long-term macrolide therapy, with accumulating evidence for inhaled therapies, physiotherapy and pulmonary rehabilitation.<\/jats:p><jats:p>This review provides a critical update on the management of bronchiectasis focussing on emerging evidence and recent randomised controlled trials.<\/jats:p>","DOI":"10.1183\/09031936.00119114","type":"journal-article","created":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T15:35:19Z","timestamp":1426865719000},"page":"1446-1462","update-policy":"https:\/\/doi.org\/10.1183\/ers-crossmark-policy","source":"Crossref","is-referenced-by-count":252,"title":["Management of bronchiectasis in adults"],"prefix":"10.1183","volume":"45","author":[{"given":"James D.","family":"Chalmers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Aliberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Blasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2015,3,18]]},"reference":[{"key":"2024102023242679000_45.5.1446.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2012.09.011"},{"key":"2024102023242679000_45.5.1446.2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136119"},{"key":"2024102023242679000_45.5.1446.3","first-page":"629","article-title":"Diagnosis and treatment of bronchiectasis. 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