{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:38:24Z","timestamp":1793191104256,"version":"4.5.0"},"reference-count":20,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2012,11,30]]},"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>The 2011 Global Initiative for Chronic Obstructive Lung Disease (GOLD) strategy document recommends assessment of chronic obstructive pulmonary disease (COPD) using symptoms and future exacerbation risk, employing two score cut-points: COPD Assessment Test (CAT) score \u226510 or modified Medical Research Council dyspnoea scale (mMRC) grade \u22652. To explore the equivalence of these two symptom cut-points, the relationship between the CAT and the mMRC and St George's Respiratory Questionnaire (SGRQ), the Short-form Health Survey and the Functional Assessment of Chronic Illness Therapy Fatigue scores were retrospectively analysed using a primary care dataset.<\/jats:p><jats:p>Data from 1817 patients (mean\u00b1<jats:sc>sd<\/jats:sc>forced expiratory volume in 1 s 1.6\u00b10.6 L) showed a significant association between mMRC grades and all health status scores (ANOVA p&lt;0.0001). mMRC grade 1 was associated with significant levels of health status impairment (SGRQ 39.4\u00b115.5 and CAT 15.7\u00b17.0); even patients with mMRC grade 0 had modestly elevated scores (SGRQ 28.5\u00b115.1 and CAT 11.7\u00b16.8). An mMRC grading \u22652 categorised 57.2% patients with low symptom (groups A and C)<jats:italic>versus<\/jats:italic>17.2% with the CAT. Using the mMRC cut-point (\u22651) resulted in similar GOLD group categorisations as the CAT (18.9%).<\/jats:p><jats:p>The mMRC showed a clear relationship with health status scores; even low mMRC grades were associated with health status impairment. Cut-points of mMRC grade \u22651 and CAT score \u226510 were approximately equivalent in determining low-symptom patients. The GOLD assessment framework may require refinement.<\/jats:p>","DOI":"10.1183\/09031936.00125612","type":"journal-article","created":{"date-parts":[[2012,12,22]],"date-time":"2012-12-22T06:15:21Z","timestamp":1356156921000},"page":"647-654","source":"Crossref","is-referenced-by-count":126,"title":["Comparisons of health status scores with MRC grades in COPD: implications for the GOLD 2011 classification"],"prefix":"10.1183","volume":"42","author":[{"given":"Paul W.","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Adamek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Nadeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Banik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2012,12,20]]},"reference":[{"key":"2024102021293003000_42.3.647.1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global Strategy for the Diagnosis, Management and Prevention of COPD. www.goldcopd.com\/guidelines-global-strategy-for-diagnosis-management.html Date last accessed: July 2012. Date last updated: February 2013."},{"key":"2024102021293003000_42.3.647.2","unstructured":"The Global Initiative for Chronic Obstructive Lung disease (GOLD). 2010 Update: GOLD Report, Global Strategy for the Diagnosis, Management and Prevention of COPD. www.goldcopd.com ."},{"key":"2024102021293003000_42.3.647.3","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1465-9921-11-122","article-title":"Characterisation of COPD heterogeneity in the ECLIPSE cohort","volume":"11","author":"Agusti","year":"2010","journal-title":"Respir Res"},{"key":"2024102021293003000_42.3.647.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00102509"},{"key":"2024102021293003000_42.3.647.5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00177210"},{"key":"2024102021293003000_42.3.647.6","first-page":"577","article-title":"The clinical diagnosis of pulmonary emphysema; an experimental study","volume":"45","author":"Fletcher","year":"1952","journal-title":"Proc R Soc Med"},{"key":"2024102021293003000_42.3.647.7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.93.3.580"},{"key":"2024102021293003000_42.3.647.8","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.7.581"},{"key":"2024102021293003000_42.3.647.9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.rmed.2010.09.004","article-title":"Health-related quality of life in patients by COPD severity within primary care in Europe","volume":"1","author":"Jones","year":"2011","journal-title":"Respir Med"},{"key":"2024102021293003000_42.3.647.10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-0702"},{"key":"2024102021293003000_42.3.647.11","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199603000-00003"},{"key":"2024102021293003000_42.3.647.12","first-page":"604","article-title":"The Functional Assessment of Chronic Illness Therapy (FACIT) measurement system: validation of version 4 of the core questionnaire","volume":"8","author":"Webster","year":"1999","journal-title":"Qual Life Res"},{"key":"2024102021293003000_42.3.647.13","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00063702"},{"key":"2024102021293003000_42.3.647.14","doi-asserted-by":"publisher","DOI":"10.1177\/0163278705275340"},{"key":"2024102021293003000_42.3.647.15","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-5-55"},{"key":"2024102021293003000_42.3.647.16","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00213202"},{"key":"2024102021293003000_42.3.647.17","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.115725"},{"key":"2024102021293003000_42.3.647.18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805800"},{"key":"2024102021293003000_42.3.647.19","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-1830"},{"key":"2024102021293003000_42.3.647.20","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-11-42"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00125612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:42:08Z","timestamp":1740379328000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00125612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,20]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,9,2]]},"published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1183\/09031936.00125612"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00125612","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,20]]}}}