{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:54:40Z","timestamp":1790258080474,"version":"4.1.0"},"reference-count":31,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2008,3,18]]},"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p>Improved survival following extreme preterm birth complicated by bronchopulmonary dysplasia (BPD) is resulting in an increasing number of affected infants surviving to adulthood. The aim of the present pilot study was to describe the functional and structural pulmonary sequelae of moderate and severe BPD in a population of adult survivors.<\/jats:p><jats:p>All babies were cared for at one institution (King Edward Memorial Hospital, Subiaco, Australia). Subjects born between 1980 and 1987 with birthweight &lt;1,500\u2005g and requiring supplementary oxygen at 36\u2005weeks post-menstrual age were identified from a complete neonatal database and recruited prospectively. Local physicians were concurrently asked to refer suitable patients. Demographics, respiratory symptoms and examination results, pulmonary function tests and computed tomography images were acquired.<\/jats:p><jats:p>In total, 21 subjects were studied. Of these, 12 were female, the median (range) age was 19 (17\u201333)\u2005yrs and 15 (71%) had persistent respiratory symptoms. The median (range) forced expiratory volume in one second (FEV<jats:sub>1<\/jats:sub>) z-score was -0.77 (-8.20\u20131.37), the forced expiratory flow at 25\u201375% of forced vital capacity was -1.81 (-6.00\u20130.75) and the diffusing capacity of the lung for carbon monoxide was -5.04 (-13.17\u2013\u2009-1.24). Computed tomography was carried out on 19 subjects and all had abnormal findings, with emphysema being the most common, present in 84% of subjects. The extent of radiological emphysema was inversely related to the FEV<jats:sub>1<\/jats:sub>z-score.<\/jats:p><jats:p>Young adult survivors of moderate and severe bronchopulmonary dysplasia may be left with residual functional and characteristic structural pulmonary abnormalities, most notably emphysema.<\/jats:p>","DOI":"10.1183\/09031936.00127107","type":"journal-article","created":{"date-parts":[[2008,4,3]],"date-time":"2008-04-03T00:26:58Z","timestamp":1207182418000},"page":"321-328","source":"Crossref","is-referenced-by-count":269,"title":["Emphysema in young adult survivors of moderate-to-severe bronchopulmonary dysplasia"],"prefix":"10.1183","volume":"32","author":[{"given":"P. M.","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. N.","family":"Lees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Louw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Gain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. P.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. C.","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2008,4,2]]},"reference":[{"key":"2024102019344030000_32.2.321.1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"2024102019344030000_32.2.321.2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.4.317"},{"key":"2024102019344030000_32.2.321.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01323.x"},{"key":"2024102019344030000_32.2.321.4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.1999.00422.x"},{"key":"2024102019344030000_32.2.321.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70353-0"},{"key":"2024102019344030000_32.2.321.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70219-7"},{"key":"2024102019344030000_32.2.321.7","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/ppul.1950080404","volume":"8","year":"1990","journal-title":"Pediatr Pulmonol"},{"key":"2024102019344030000_32.2.321.8","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1542\/peds.89.6.1151","volume":"89","year":"1992","journal-title":"Pediatrics"},{"key":"2024102019344030000_32.2.321.9","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/ppul.1950200506","volume":"20","year":"1995","journal-title":"Pediatr Pulmonol"},{"key":"2024102019344030000_32.2.321.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80483-4"},{"key":"2024102019344030000_32.2.321.11","doi-asserted-by":"publisher","DOI":"10.1136\/adc.84.1.40"},{"key":"2024102019344030000_32.2.321.12","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1440-1754.1996.tb02566.x","volume":"32","year":"1996","journal-title":"J Paediatr Child Health"},{"key":"2024102019344030000_32.2.321.13","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199601)21:1<28::AID-PPUL5>3.0.CO;2-M"},{"key":"2024102019344030000_32.2.321.14","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2214\/ajr.173.4.10511158","volume":"173","year":"1999","journal-title":"AJR Am J Roentgenol"},{"key":"2024102019344030000_32.2.321.15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199012273232603"},{"key":"2024102019344030000_32.2.321.16","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.565"},{"key":"2024102019344030000_32.2.321.17","doi-asserted-by":"publisher","DOI":"10.1080\/08035250410028101"},{"key":"2024102019344030000_32.2.321.18","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200507-1140OC"},{"key":"2024102019344030000_32.2.321.19","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2522"},{"key":"2024102019344030000_32.2.321.20","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.0383"},{"key":"2024102019344030000_32.2.321.21","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.2214\/ajr.174.5.1741323","volume":"174","year":"2000","journal-title":"AJR Am J Roentgenol"},{"key":"2024102019344030000_32.2.321.22","first-page":"725","volume":"127","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"2024102019344030000_32.2.321.23","first-page":"419","volume":"18","year":"1982","journal-title":"Bull Eur Physiopathol Respir"},{"key":"2024102019344030000_32.2.321.24","doi-asserted-by":"publisher","DOI":"10.1183\/09041950.041s1693"},{"key":"2024102019344030000_32.2.321.25","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.2.7633722"},{"key":"2024102019344030000_32.2.321.26","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.1.8680679"},{"key":"2024102019344030000_32.2.321.27","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.054890"},{"key":"2024102019344030000_32.2.321.28","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200611-1660PP"},{"key":"2024102019344030000_32.2.321.29","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1542\/peds.90.6.899","volume":"90","year":"1992","journal-title":"Pediatrics"},{"key":"2024102019344030000_32.2.321.30","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1148\/radiology.171.3.2717757","volume":"171","year":"1989","journal-title":"Radiology"},{"key":"2024102019344030000_32.2.321.31","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.2214\/ajr.179.6.1791407","volume":"179","year":"2002","journal-title":"AJR Am J Roentgenol"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00127107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:10:07Z","timestamp":1740377407000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00127107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,2]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,7,31]]},"published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1183\/09031936.00127107"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00127107","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,2]]}}}