{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:05:28Z","timestamp":1791821128856,"version":"4.3.4"},"reference-count":42,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2012,9,27]]},"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Interferon (IFN)-\u03b3 release assays (IGRAs) are probably the most accurate tests for the detection of latent<jats:italic>Mycobacterium tuberculosis<\/jats:italic>infection, but IGRAs are labour intensive and the transport of samples over longer distances is difficult. IFN-\u03b3-induced protein (IP)-10 is expressed at 100-fold higher levels than IFN-\u03b3, and IP-10 release assays have comparable performance to IGRAs. The aim of this study was to explore the diagnostic potential of a novel IP-10 release assay based on dried plasma spots (DPS).<\/jats:p><jats:p>The presence of IP-10 and IFN-\u03b3 was determined in plasma and in DPS by ELISA. Diagnostic algorithms for plasma and DPS tests for IP-10 were developed on a training cohort comprising 60 tuberculosis (TB) patients and 59 healthy controls. Diagnostic accuracy was assessed in a validation cohort comprising 78 TB patients and 98 healthy controls. Plasma was measured in Spain and DPS samples were sent to Denmark using the conventional postal service for analysis.<\/jats:p><jats:p>IP-10 was readily detectable in both plasma and DPS, and correlation was excellent (r<jats:sup>2<\/jats:sup>= 0.95). QuantiFERON-TB Gold In-Tube (QFT-TB) and IP-10 in DPS and plasma rendered comparable sensitivity (78%, 82% and 84%, respectively), specificity (100%, 97% and 97%, respectively) and indeterminate rates (p&gt;0.55).<\/jats:p><jats:p>The DPS-based IP-10 test has comparable diagnostic accuracy to the QFT-TB and samples can be sent<jats:italic>via<\/jats:italic>conventional mail over long distances for analysis without affecting the results.<\/jats:p>","DOI":"10.1183\/09031936.00129412","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T04:49:27Z","timestamp":1359089367000},"page":"495-503","source":"Crossref","is-referenced-by-count":40,"title":["Dried plasma spots in the diagnosis of tuberculosis: IP-10 release assay on filter paper"],"prefix":"10.1183","volume":"42","author":[{"given":"Martine 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