{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:10:39Z","timestamp":1790010639124,"version":"4.0.1"},"reference-count":35,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2013,5,20]]},"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Endobronchial valve (EBV) therapy may be associated with improvements in chronic obstructive pulmonary disease-related outcomes and may therefore be linked to improvements in the body mass index, airflow obstruction, dyspnoea, exercise capacity (BODE) index.<\/jats:p>\n                  <jats:p>Data from 416 patients with advanced emphysema and hyperinflation across Europe and USA, who were randomised to EBV (n=284) or conservative therapy (n=132) were analysed. Quantitative image analysis was used to compare the volume of the targeted lobe at baseline and at 6 months to determine target lobe volume reduction (TLVR).<\/jats:p>\n                  <jats:p>\n                    44% of patients receiving EBV therapy (\n                    <jats:italic>versus<\/jats:italic>\n                    24.7% of controls) had clinically significant improvements in the BODE index (p&lt;0.001). BODE index was significantly reduced by mean\u00b1\n                    <jats:sc>sd<\/jats:sc>\n                    1.4\u00b11.8, 0.2\u00b11.3 and 0.1\u00b11.3 points in patients with TLVR &gt;50%, 20%\u201350% and &lt;20%, respectively (intergroup differences p&lt;0.001), but increased by 0.3\u00b11.2 points in controls. Changes in BODE were predicted by baseline BODE and correlated significantly with lobar exclusion and lung volumes at 6 months.\n                  <\/jats:p>\n                  <jats:p>A greater proportion of patients in the treatment group than in the control group achieved a clinically meaningful improvement in BODE index; however, the likelihood of benefit was less than half in both groups. Patients in whom TLVR was obtained had greater improvements in clinical outcomes.<\/jats:p>","DOI":"10.1183\/09031936.00133012","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T22:55:46Z","timestamp":1373583346000},"page":"387-396","source":"Crossref","is-referenced-by-count":61,"title":["Target lobe volume reduction and COPD outcome measures after endobronchial valve therapy"],"prefix":"10.1183","volume":"43","author":[{"given":"Arschang","family":"Valipour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix J.F.","family":"Herth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto 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