{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:19:22Z","timestamp":1791289162838,"version":"4.3.0"},"reference-count":39,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2008,2,11]]},"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p>Severity of oxygen desaturation is predictive of early atherosclerosis in obstructive sleep apnoea (OSA). Leukotriene (LT)B<jats:sub>4<\/jats:sub>is a lipid mediator involved in atherogenesis.<\/jats:p><jats:p>In 40 non-obese OSA patients, free of a cardiovascular history, and 20 healthy volunteers, the following were evaluated: 1) LTB<jats:sub>4<\/jats:sub>production by polymorphonuclear leukocytes (PMNs) stimulated with A23187; and 2) the relationships between LTB<jats:sub>4<\/jats:sub>production and both OSA severity and infraclinical atherosclerosis markers. The effect of continuous positive airway pressure (CPAP) on LTB<jats:sub>4<\/jats:sub>production was also studied. An overnight sleep study was followed by first-morning blood sampling. Isolated PMNs were stimulated with A23187 in order to induce LTB<jats:sub>4<\/jats:sub>production, which was measured by liquid chromatography\u2013tandem mass spectrometry. Carotid intima-media thickness (IMT) and luminal diameter were measured in subset groups of 28 OSA patients and 11 controls.<\/jats:p><jats:p>LTB<jats:sub>4<\/jats:sub>production was increased in OSA patients compared with controls. LTB<jats:sub>4<\/jats:sub>levels correlated with the mean and minimal arterial oxygen saturation (<jats:italic>S<\/jats:italic><jats:sub>a,O<jats:sub>2<\/jats:sub><\/jats:sub>). LTB<jats:sub>4<\/jats:sub>production correlated with luminal diameter data in patients with a mean<jats:italic>S<\/jats:italic><jats:sub>a,O<jats:sub>2<\/jats:sub><\/jats:sub>of \u226494% but not with IMT. Lastly, CPAP significantly reduced LTB<jats:sub>4<\/jats:sub>production by 50%.<\/jats:p><jats:p>Leukotriene B<jats:sub>4<\/jats:sub>production is increased in obstructive sleep apnoea in relation to oxygen desaturation. Leukotriene B<jats:sub>4<\/jats:sub>could promote early vascular remodelling in moderate-to-severe hypoxic obstructive sleep apnoea patients.<\/jats:p>","DOI":"10.1183\/09031936.00137107","type":"journal-article","created":{"date-parts":[[2008,3,6]],"date-time":"2008-03-06T01:34:39Z","timestamp":1204767279000},"page":"113-120","source":"Crossref","is-referenced-by-count":52,"title":["Leukotriene B<sub>4<\/sub>: early mediator of atherosclerosis in obstructive sleep 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