{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:27:49Z","timestamp":1793143669746,"version":"4.5.0"},"reference-count":36,"publisher":"European Respiratory Society (ERS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2008,2,11]]},"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p>Clock genes regulate mammalian circadian rhythms, and dysfunction of clock genes can contribute to various disorders. To investigate whether obstructive sleep apnoea syndrome (OSAS) influences clock gene function, the present authors examined<jats:italic>Period1<\/jats:italic>(<jats:italic>Per1<\/jats:italic>) mRNA expression<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>.<\/jats:p><jats:p>In eight healthy subjects and eight OSAS patients, plasma noradrenaline, serum interleukin (IL)-6, high-sensitivity C-reactive protein (hsCRP) and<jats:italic>Per1<\/jats:italic>mRNA expression in peripheral whole blood were measured. Expression of<jats:italic>Per1<\/jats:italic>mRNA in cultured cells was examined under IL-6 or noradrenaline stimulation<jats:italic>in vitro<\/jats:italic>. After noradrenaline was administered to mice<jats:italic>in vivo<\/jats:italic>,<jats:italic>Per1<\/jats:italic>mRNA expression in the brain was examined.<\/jats:p><jats:p>The concentrations of serum IL-6, hsCRP and plasma noradrenaline were elevated in OSAS patients, but improved by continuous positive airway pressure (CPAP) therapy.<jats:italic>Per1<\/jats:italic>mRNA expression in the peripheral blood significantly decreased at 02:00\u2009h by CPAP in OSAS patients. Stimulation with IL-6 did not directly induce<jats:italic>Per1<\/jats:italic>mRNA<jats:italic>in vitro<\/jats:italic>. Administration of noradrenaline induced<jats:italic>Per1<\/jats:italic>mRNA in the cerebral cortex of mice<jats:italic>in vivo<\/jats:italic>.<\/jats:p><jats:p>The current study revealed that obstructive sleep apnoea syndrome caused clock gene dysfunction, and continuous positive airway pressure helped to improve it. Sympathetic activation and elevation of the plasma noradrenaline concentration in obstructive sleep apnoea syndrome may be one of the factors involved in disorders of<jats:italic>Period1<\/jats:italic>mRNA expression.<\/jats:p>","DOI":"10.1183\/09031936.00138207","type":"journal-article","created":{"date-parts":[[2008,3,6]],"date-time":"2008-03-06T01:34:39Z","timestamp":1204767279000},"page":"105-112","source":"Crossref","is-referenced-by-count":71,"title":["Clock gene dysfunction in patients with obstructive sleep apnoea syndrome"],"prefix":"10.1183","volume":"32","author":[{"given":"N.","family":"Burioka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Koyanagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Fukuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Chikumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ohdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2008,3,5]]},"reference":[{"key":"2024102019330717000_32.1.105.1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00177.2002"},{"key":"2024102019330717000_32.1.105.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200601-066OC"},{"key":"2024102019330717000_32.1.105.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052627.99976.18"},{"key":"2024102019330717000_32.1.105.4","doi-asserted-by":"publisher","DOI":"10.1385\/IR:24:2:163"},{"key":"2024102019330717000_32.1.105.5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00043306"},{"key":"2024102019330717000_32.1.105.6","doi-asserted-by":"publisher","DOI":"10.1177\/0748730403018003007"},{"key":"2024102019330717000_32.1.105.7","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1072"},{"key":"2024102019330717000_32.1.105.8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502383102"},{"key":"2024102019330717000_32.1.105.9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00582.2005"},{"key":"2024102019330717000_32.1.105.10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0779"},{"key":"2024102019330717000_32.1.105.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.04.065"},{"key":"2024102019330717000_32.1.105.12","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.90.263"},{"key":"2024102019330717000_32.1.105.13","doi-asserted-by":"publisher","DOI":"10.1080\/07420520601140043"},{"key":"2024102019330717000_32.1.105.14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00126.2005"},{"key":"2024102019330717000_32.1.105.15","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FMJ06003X4"},{"key":"2024102019330717000_32.1.105.16","doi-asserted-by":"publisher","DOI":"10.1080\/07420520500179167"},{"key":"2024102019330717000_32.1.105.17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102075599"},{"key":"2024102019330717000_32.1.105.18","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6166"},{"key":"2024102019330717000_32.1.105.19","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0165"},{"key":"2024102019330717000_32.1.105.20","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.24.7128"},{"key":"2024102019330717000_32.1.105.21","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5488.2344"},{"key":"2024102019330717000_32.1.105.22","doi-asserted-by":"publisher","DOI":"10.1081\/CBI-200062416"},{"key":"2024102019330717000_32.1.105.23","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:18:1-2:105"},{"key":"2024102019330717000_32.1.105.24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0936797100"},{"key":"2024102019330717000_32.1.105.25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.1996.00006.x"},{"key":"2024102019330717000_32.1.105.26","doi-asserted-by":"publisher","DOI":"10.1080\/07435800500456895"},{"key":"2024102019330717000_32.1.105.27","unstructured":"Rechtschaffen A, Kales A. 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