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These patients usually do not achieve satisfactory disease control with conventional treatment of severe asthma,<jats:italic>i.e.<\/jats:italic>high-dose inhaled corticosteroids and long-acting bronchodilators. Although prolonged systemic corticosteroids are effective, they carry a substantial toxicity profile. Supplementary or alternative therapies have primarily focused on use of antifungal agents including oral triazoles and inhaled amphotericin B. Immunomodulation with omalizumab, a humanised anti-IgE monoclonal antibody, or \"pulse\" monthly high-dose intravenous corticosteroid, has also been employed. This article considers the experience with these approaches, with emphasis on recent clinical trials.<\/jats:p>","DOI":"10.1183\/09031936.00139513","type":"journal-article","created":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T02:08:36Z","timestamp":1386295716000},"page":"1487-1500","source":"Crossref","is-referenced-by-count":84,"title":["Treatment options in severe fungal asthma and allergic bronchopulmonary aspergillosis"],"prefix":"10.1183","volume":"43","author":[{"given":"Richard B.","family":"Moss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2013,12,5]]},"reference":[{"key":"2024102022184314000_43.5.1487.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.12.970"},{"key":"2024102022184314000_43.5.1487.2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7361.411"},{"key":"2024102022184314000_43.5.1487.3","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-5-4"},{"key":"2024102022184314000_43.5.1487.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00074705"},{"key":"2024102022184314000_43.5.1487.5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201001-0087OC"},{"key":"2024102022184314000_43.5.1487.6","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.504752"},{"key":"2024102022184314000_43.5.1487.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02542.x"},{"key":"2024102022184314000_43.5.1487.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03944.x"},{"key":"2024102022184314000_43.5.1487.9","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-011-0217-4"},{"key":"2024102022184314000_43.5.1487.10","first-page":"936","article-title":"Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma: systematic review and meta-analysis","volume":"13","author":"Agarwal","year":"2009","journal-title":"Int J Tuberc Lung Dis"},{"key":"2024102022184314000_43.5.1487.11","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1295716"},{"key":"2024102022184314000_43.5.1487.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2012.04.008"},{"key":"2024102022184314000_43.5.1487.13","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12141"},{"key":"2024102022184314000_43.5.1487.14","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.6.ats9-00"},{"key":"2024102022184314000_43.5.1487.15","doi-asserted-by":"crossref","unstructured":"Moss RB . 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