{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:15:47Z","timestamp":1791033347696,"version":"4.1.0"},"reference-count":28,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2009,2,23]]},"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p>The present study verified the hypothesis that enhanced maturation of antigen-presenting CD11c<jats:sup>+<\/jats:sup>cells could explain the viral-induced exacerbated immune response to<jats:italic>Saccharopolyspora rectivirgula<\/jats:italic>(SR), the main antigen responsible for farmer\u2019s lung, a classic form of hypersensitivity pneumonitis (HP).<\/jats:p><jats:p>Four groups of mice were studied: group 1 received intranasal instillations of saline; group 2 received instillations of SR for 12\u2005weeks; group 3 received instillations of saline and a single infection with Sendai virus on week 3; and group 4 received instillations of SR for 12\u2005weeks with a single administration of Sendai virus on week 3. On week 13, mice were sacrificed and bronchoalveolar lavage was performed. Lungs were harvested, digested with enzymes, and CD11c<jats:sup>+<\/jats:sup>cells were analysed in flow cytometry with anti-CD11c, anti-CD86 and anti-major histocompatibility complex class II markers. Immunofluorescence studies were also performed with the same cell surface markers.<\/jats:p><jats:p>Both flow cytometry and immunofluorescence results demonstrate that mature CD11c<jats:sup>+<\/jats:sup>cells are significantly enhanced in SR-challenged mice simultaneously infected with Sendai virus, compared with other groups. These CD11c<jats:sup>+<\/jats:sup>cells persist in the lung for 9\u2005weeks after the virus infection.<\/jats:p><jats:p>Maturation of CD11c<jats:sup>+<\/jats:sup>cells could explain, at least in part, the virus-induced increased immune response to SR antigens in this model of HP, but mechanisms have still to be elucidated.<\/jats:p>","DOI":"10.1183\/09031936.00140908","type":"journal-article","created":{"date-parts":[[2009,3,13]],"date-time":"2009-03-13T00:44:47Z","timestamp":1236905087000},"page":"749-756","source":"Crossref","is-referenced-by-count":17,"title":["Mature CD11c<sup>+<\/sup>cells are enhanced in hypersensitivity pneumonitis"],"prefix":"10.1183","volume":"34","author":[{"given":"M.","family":"Girard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Isra\u00ebl-Assayag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Cormier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2009,3,12]]},"reference":[{"key":"2024102019523542000_34.3.749.1","unstructured":"Cormier Y, Isra\u00ebl-Assayag E. 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