{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:37:31Z","timestamp":1791218251529,"version":"4.1.0"},"reference-count":24,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,12,26]]},"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>Previous studies have reported mortality rates of up to 56% associated with pregnancy in pulmonary arterial hypertension (PAH) but the management of this disease has changed considerably in recent years.<\/jats:p><jats:p>We compiled a multinational, prospective registry to examine the contemporary outcome of pregnancies in patients with PAH.<\/jats:p><jats:p>During a 3-yr period, the 13 participating centres reported 26 pregnancies. Three (12%) females died and one (4%) developed right heart failure requiring urgent heart\u2013lung transplantation. There were eight abortions; two spontaneous and six induced. 16 (62%) pregnancies were successful,<jats:italic>i.e.<\/jats:italic>the females delivered healthy babies without complications. These females had well controlled PAH (pulmonary vascular resistance (PVR) 500\u00b1352 dyn\u00b7s\u00b7cm<jats:sup>\u22125<\/jats:sup>); eight of them were long-term responders to calcium channel blockers. In contrast, the females who died or required transplantation had poorly controlled PAH (PVR 1,667\u00b1209 dyn\u00b7s\u00b7cm<jats:sup>\u22125<\/jats:sup>).<\/jats:p><jats:p>Pregnancy remains associated with a substantial mortality rate in PAH. However, our results indicate that the outcome of pregnancy in PAH has improved, at least when PAH is well controlled, and particularly in long-term responders to calcium channel blockers. These data must be confirmed by larger series before the general recommendation to avoid pregnancy in all patients with PAH is reconsidered.<\/jats:p>","DOI":"10.1183\/09031936.00141211","type":"journal-article","created":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T02:14:56Z","timestamp":1327630496000},"page":"881-885","source":"Crossref","is-referenced-by-count":231,"title":["Pregnancy outcomes in pulmonary arterial hypertension in the modern management era"],"prefix":"10.1183","volume":"40","author":[{"given":"Xavier","family":"Ja\u00efs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M.","family":"Olsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan A.","family":"Barbera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Torbicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Peacock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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