{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:19:44Z","timestamp":1793060384773,"version":"4.5.0"},"reference-count":30,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2010,11,26]]},"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>The reproducibility of the 6-min walking test (6MWT) needs to be more solidly studied. This study aimed to investigate the reproducibility of two 6MWTs performed on subsequent days in a large and representative sample of patients with chronic obstructive pulmonary disease (COPD), and to quantify the learning effect between the two tests, as well as its determinants.<\/jats:p><jats:p>In a retrospective observational study, 1,514 patients with COPD performed two 6MWTs on subsequent days. Other measurements included body composition (dual X-ray absorptiometry), dyspnoea (Medical Research Council scale) and comorbidity (Charlson index).<\/jats:p><jats:p>Although the 6MWT was reproducible (intraclass correlation coefficient = 0.93), patients walked farther in the second test (391 m, 95% CI 155\u2013585 m<jats:italic>versus<\/jats:italic>418 m, 95% CI 185\u2013605 m; p&lt;0.0001). On average, the second 6MWT increased by 27 m (or 7%), and 82% of patients improved in the second test. Determinants of improvement \u226542 m in the second test (upper limit of the clinically important change) were as follows: first 6MWT &lt;350 m, Charlson index &lt;2 and body mass index &lt;30 kg\u00b7m<jats:sup>\u22122<\/jats:sup>(OR 2.49, 0.76 and 0.60, respectively).<\/jats:p><jats:p>The 6MWT was statistically reproducible in a representative sample of patients with COPD. However, the vast majority of patients improved significantly in the second test by an average learning effect of 27 m.<\/jats:p>","DOI":"10.1183\/09031936.00142010","type":"journal-article","created":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T03:29:00Z","timestamp":1293074940000},"page":"261-267","source":"Crossref","is-referenced-by-count":179,"title":["Reproducibility of 6-minute walking test in patients with COPD"],"prefix":"10.1183","volume":"38","author":[{"given":"N.A.","family":"Hernandes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.F.M.","family":"Wouters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Annegarn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pitta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Spruit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2010,12,22]]},"reference":[{"key":"2024102020313340000_38.2.261.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200703-456SO"},{"key":"2024102020313340000_38.2.261.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200407-855OC"},{"key":"2024102020313340000_38.2.261.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.07.003"},{"key":"2024102020313340000_38.2.261.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00046906"},{"key":"2024102020313340000_38.2.261.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.12.007"},{"key":"2024102020313340000_38.2.261.6","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"2024102020313340000_38.2.261.7","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00140507"},{"key":"2024102020313340000_38.2.261.8","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00099306"},{"key":"2024102020313340000_38.2.261.9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00034603"},{"key":"2024102020313340000_38.2.261.10","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200203-166OC"},{"key":"2024102020313340000_38.2.261.11","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.10.781"},{"key":"2024102020313340000_38.2.261.12","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2002.1363"},{"key":"2024102020313340000_38.2.261.13","doi-asserted-by":"publisher","DOI":"10.1136\/thx.39.11.818"},{"key":"2024102020313340000_38.2.261.14","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2002.1462"},{"key":"2024102020313340000_38.2.261.15","doi-asserted-by":"publisher","DOI":"10.1159\/000220343"},{"key":"2024102020313340000_38.2.261.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(03)00119-4"},{"key":"2024102020313340000_38.2.261.17","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.02092001"},{"key":"2024102020313340000_38.2.261.18","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1164\/ajrccm.160.5.9808139","article-title":"Comparison of hallway and treadmill six-minute walk tests","volume":"160","author":"Stevens","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2024102020313340000_38.2.261.19","doi-asserted-by":"crossref","unstructured":"Spencer LM Alison JA McKeough ZJ . 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