{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:45:47Z","timestamp":1774122347817,"version":"3.50.1"},"reference-count":30,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2009,11,18]]},"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>Nutritional status deteriorates along with progression of emphysema, with the decline of body composition correlating with risk of disease-related events. Lung volume reduction surgery (LVRS), by improving respiratory function and recovering body composition, may influence long-term disease-related morbidity and mortality when compared to respiratory rehabilitation (RR).<\/jats:p><jats:p>In this non-randomised study, 44 male patients with moderate-to-severe emphysema underwent LVRS, while 35 received RR. Respiratory parameters, body composition, number and time-to-occurrence of disease-related events were evaluated for 5 yrs.<\/jats:p><jats:p>After LVRS, respiratory and nutritional parameters had significantly greater and longer lasting improvements than after RR. Disease-related events occurred later and less frequently after surgery than after rehabilitation, with better morbidity and mortality survival curves (p&lt;0.01 and p&lt;0.03, respectively). Body mass index (BMI) \u226523kg\u00b7m<jats:sup>\u22122<\/jats:sup>, BODE (BMI, airflow obstruction, dyspnoea, exercise capacity) index \u22642 and fat-free mass index (FFMI) \u226516kg\u00b7m<jats:sup>\u22122<\/jats:sup>at 1 yr were the best positive predictors of post-operative outcomes (p&lt;0.03, p&lt;0.04 and p&lt;0.005, respectively). Reduction in residual volume at 36 months after surgery was significantly correlated with the increase of BMI (<jats:italic>\u03c1<\/jats:italic>= -0.56, p = 0.009) and FFMI (<jats:italic>\u03c1<\/jats:italic>= -0.64, p = 0.001).<\/jats:p><jats:p>LVRS significantly and durably improved respiratory function and body composition over RR. Relationships among residual volume, BMI, FFMI and disease-related events suggest that recovery in respiratory dynamics improves nutritional status, thus significantly reducing long-term disease-related morbidity and mortality.<\/jats:p>","DOI":"10.1183\/09031936.00142309","type":"journal-article","created":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:30:36Z","timestamp":1280622636000},"page":"408-416","source":"Crossref","is-referenced-by-count":15,"title":["Recovery of body composition improves long-term outcomes after lung volume reduction surgery for 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