{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:46:37Z","timestamp":1790023597435,"version":"4.0.1"},"reference-count":37,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2013,1,14]]},"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>Chronic obstructive pulmonary disease (COPD) is associated with increased cardiovascular mortality. Endothelial dysfunction may underpin this association. This cross-sectional study aimed to determine the impact of airflow obstruction, systemic inflammation, oxidative stress, sympathetic activation, hypoxaemia and physical activity on endothelial function in COPD.<\/jats:p><jats:p>In stable COPD patients, assessments of endothelial function by flow-mediated dilatation (FMD), cardiovascular risk (Pocock score), airflow obstruction (forced expiratory volume in 1 s (FEV<jats:sub>1<\/jats:sub>)), systemic inflammation (high-sensitivity C-reactive protein and interleukin-6), oxidative stress (malondialdehyde), sympathetic activation (baroreflex sensitivity), hypoxaemia (arterial oxygen tension), hypercapnia (arterial carbon dioxide tension (<jats:italic>P<\/jats:italic><jats:sub>aCO<jats:sub>2<\/jats:sub><\/jats:sub>)), physical activity (steps per day) and exercise capacity (6-min walking distance) were performed. Associations between FMD and potential determinants were assessed in univariate and multivariate analyses.<\/jats:p><jats:p>106 patients (Global Initiative for Chronic Obstructive Lung Disease stage I\/II 35%, stage III 25% and stage IV 40%) were included. In multivariate analysis FEV<jats:sub>1<\/jats:sub>was positively associated with FMD, independent of other significant FMD determinants from univariate analysis (sex, smoking, combined inhaled long-acting \u03b2-adrenergic and steroid medication, heart rate, baroreflex sensitivity and<jats:italic>P<\/jats:italic><jats:sub>aCO<jats:sub>2<\/jats:sub><\/jats:sub>) and adjusted for potential confounders (cardiovascular risk and age). In addition, the FMD and FEV<jats:sub>1<\/jats:sub>association was modified by physical activity.<\/jats:p><jats:p>The findings of this study demonstrate that the severity of airflow obstruction is a significant determinant of endothelial function in patients with COPD. A high level of physical activity seems to have a favourable effect on this association.<\/jats:p>","DOI":"10.1183\/09031936.00144612","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T04:04:25Z","timestamp":1361505865000},"page":"1194-1204","source":"Crossref","is-referenced-by-count":100,"title":["Determinants of endothelial function in patients with COPD"],"prefix":"10.1183","volume":"42","author":[{"given":"Christian F.","family":"Clarenbach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Senn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriane A.","family":"Sievi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Camen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnoldus 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