{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:40:02Z","timestamp":1774125602424,"version":"3.50.1"},"reference-count":35,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2007,4,19]]},"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p>The aim of the present study was to assess the cost-effectiveness of the new T-SPOT.<jats:italic>TB<\/jats:italic>assay<jats:italic>versus<\/jats:italic>the tuberculin skin test (TST) for screening contacts for latent tuberculosis (TB) infection in Switzerland.<\/jats:p><jats:p>Health and economic outcomes of isoniazid treatment of 20- and 40-yr-old close contacts were compared in a Markov model over a 20-yr period following screening with TST only (at three cut-off values) and T-SPOT.<jats:italic>TB<\/jats:italic>alone or in combination with the TST.<\/jats:p><jats:p>T-SPOT.<jats:italic>TB<\/jats:italic>-based treatment was cost-effective at \\#8342;11,621 and \\#8342;23,692 per life-year-gained (LYG) in the younger and older age group, respectively. No TST-based programmes were cost-effective, except at a 15-mm cut-off in the younger group only, where the cost-effectiveness (\\#8342;26,451\u00b7LYG<jats:sup>\u22121<\/jats:sup>) fell just below the willingness-to-pay threshold. Combination of the TST with T-SPOT.<jats:italic>TB<\/jats:italic>slightly reduced the total cost compared with the T-SPOT.<jats:italic>TB<\/jats:italic>alone by 4.4 and 5.0% in the younger and older groups respectively. The number of contacts treated to avoid one case of TB decreased from 50 (95% confidence interval 32\u2013106) with the TST (10-mm cut-off) to 18 (95%CI 11\u201343) if T-SPOT.<jats:italic>TB<\/jats:italic>was used.<\/jats:p><jats:p>Using T-SPOT.<jats:italic>TB<\/jats:italic>alone or in combination with the tuberculin skin test for screening of close contacts before latent tuberculosis infection treatment is highly cost-effective in reducing the disease burden of tuberculosis.<\/jats:p>","DOI":"10.1183\/09031936.00145906","type":"journal-article","created":{"date-parts":[[2007,5,16]],"date-time":"2007-05-16T00:39:46Z","timestamp":1179275986000},"page":"321-332","source":"Crossref","is-referenced-by-count":54,"title":["Cost-effectiveness of interferon-\u03b3 release assay testing for the treatment of latent tuberculosis"],"prefix":"10.1183","volume":"30","author":[{"given":"R.","family":"Diel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Wrighton-Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-P.","family":"Zellweger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2007,5,15]]},"reference":[{"key":"2024102019181028000_30.2.321.1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00261402"},{"key":"2024102019181028000_30.2.321.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12950-9"},{"key":"2024102019181028000_30.2.321.3","first-page":"1242","volume":"9","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"key":"2024102019181028000_30.2.321.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00107005"},{"key":"2024102019181028000_30.2.321.5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200505-748OC"},{"key":"2024102019181028000_30.2.321.6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200403-307OC"},{"key":"2024102019181028000_30.2.321.7","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00110205"},{"key":"2024102019181028000_30.2.321.8","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00011806"},{"key":"2024102019181028000_30.2.321.9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00005906"},{"key":"2024102019181028000_30.2.321.10","unstructured":"Swiss Lung League. 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