{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:42:38Z","timestamp":1793914958027,"version":"4.8.0"},"reference-count":99,"publisher":"European Respiratory Society (ERS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2013,7,1]]},"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>Chronic obstructive pulmonary disease (COPD) is linked to cardiovascular disease; however, there are few studies on the associations of cardiovascular genes with COPD.<\/jats:p><jats:p>We assessed the association of lung function with 2100 genes selected for cardiovascular diseases among 20 077 European-Americans and 6900 African-Americans. We performed replication of significant loci in the other racial group and an independent consortium of Europeans, tested the associations of significant loci with per cent emphysema and examined gene expression in an independent sample. We then tested the association of a related lipid biomarker with forced expiratory volume in 1 s (FEV<jats:sub>1<\/jats:sub>)\/forced vital capacity (FVC) ratio and per cent emphysema.<\/jats:p><jats:p>We identified one new polymorphism for FEV<jats:sub>1<\/jats:sub>\/FVC (rs805301) in European-Americans (p=1.3\u00d710<jats:sup>\u22126<\/jats:sup>) and a second (rs707974) in the combined European-American and African-American analysis (p=1.38\u00d710<jats:sup>\u22127<\/jats:sup>). Both single-nucleotide polymorphisms (SNPs) flank the gene for apolipoprotein M (<jats:italic>APOM<\/jats:italic>), a component of high-density lipoprotein (HDL) cholesterol. Both were replicated in an independent cohort. SNPs in a second gene related to apolipoprotein M and HDL,<jats:italic>PCSK9<\/jats:italic>, were associated with FEV<jats:sub>1<\/jats:sub>\/FVC ratio among African-Americans. rs707974 was associated with per cent emphysema among European-Americans and African-Americans and<jats:italic>APOM<\/jats:italic>expression was related to FEV<jats:sub>1<\/jats:sub>\/FVC ratio and per cent emphysema. Higher HDL levels were associated with lower FEV<jats:sub>1<\/jats:sub>\/FVC ratio and greater per cent emphysema.<\/jats:p><jats:p>These findings suggest a novel role for the apolipoprotein M\/HDL pathway in the pathogenesis of COPD and emphysema.<\/jats:p>","DOI":"10.1183\/09031936.00147612","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T07:34:22Z","timestamp":1375256062000},"page":"1003-1017","source":"Crossref","is-referenced-by-count":52,"title":["<i>APOM<\/i>and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema"],"prefix":"10.1183","volume":"43","author":[{"given":"Kristin M.","family":"Burkart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ani","family":"Manichaikul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemma B.","family":"Wilk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firas S.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory L.","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Enright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia N.","family":"Hansel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demondes","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Heckbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D.","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Loehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J.","family":"London","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George T.","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Oelsner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcy","family":"Petrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tess D.","family":"Pottinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Redline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome I.","family":"Rotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Soler Artigas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin D.","family":"Tobin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Y.","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor R.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen S.","family":"Rich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Graham","family":"Barr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2013,7,30]]},"reference":[{"key":"2024102021475498000_43.4.1003.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"2024102021475498000_43.4.1003.2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540270072029"},{"key":"2024102021475498000_43.4.1003.3","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.5.2101039"},{"key":"2024102021475498000_43.4.1003.4","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(58)90199-2"},{"key":"2024102021475498000_43.4.1003.5","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.6.9706014"},{"key":"2024102021475498000_43.4.1003.6","doi-asserted-by":"publisher","DOI":"10.1086\/340316"},{"key":"2024102021475498000_43.4.1003.7","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.8.2105002"},{"key":"2024102021475498000_43.4.1003.8","doi-asserted-by":"crossref","unstructured":"Cho MH McDonald M-LN Zhou X . Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med 2014 [In press DOI: 10.1016\/S2213-2600(14)70002-5].","DOI":"10.1016\/S2213-2600(14)70002-5"},{"key":"2024102021475498000_43.4.1003.9","doi-asserted-by":"publisher","DOI":"10.1038\/ng.941"},{"key":"2024102021475498000_43.4.1003.10","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201202-0366OC"},{"key":"2024102021475498000_43.4.1003.11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003098"},{"key":"2024102021475498000_43.4.1003.12","doi-asserted-by":"publisher","DOI":"10.1038\/ng.501"},{"key":"2024102021475498000_43.4.1003.13","doi-asserted-by":"publisher","DOI":"10.1038\/ng.500"},{"key":"2024102021475498000_43.4.1003.14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000429"},{"key":"2024102021475498000_43.4.1003.15","doi-asserted-by":"publisher","DOI":"10.1038\/ng.535"},{"key":"2024102021475498000_43.4.1003.16","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201102-0192OC"},{"key":"2024102021475498000_43.4.1003.17","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2011-0055OC"},{"key":"2024102021475498000_43.4.1003.18","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200801-059OC"},{"key":"2024102021475498000_43.4.1003.19","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201004-0541OC"},{"key":"2024102021475498000_43.4.1003.20","doi-asserted-by":"crossref","unstructured":"Manichaikul A Hoffman EA Smolonska J . Genome-wide Study of Percent Emphysema on CT in the General Population: The MESA Lung\/SHARe Study. Am J Respir Crit Care Med 2014 [In press DOI: 10.1164\/rccm.201306-1061OC].","DOI":"10.1164\/rccm.201306-1061OC"},{"key":"2024102021475498000_43.4.1003.21","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200612-1797OC"},{"key":"2024102021475498000_43.4.1003.22","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0427OC"},{"key":"2024102021475498000_43.4.1003.23","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200909-1364OC"},{"key":"2024102021475498000_43.4.1003.24","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-9"},{"key":"2024102021475498000_43.4.1003.25","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2011.118"},{"key":"2024102021475498000_43.4.1003.26","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3109\/15412555.2012.676110","article-title":"Association between genetic variations in surfactant protein D and emphysema, interstitial pneumonia, and lung cancer in a Japanese population","volume":"9","author":"Ishii","year":"2012","journal-title":"COPD"},{"key":"2024102021475498000_43.4.1003.27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003583"},{"key":"2024102021475498000_43.4.1003.28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M804595200"},{"key":"2024102021475498000_43.4.1003.29","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43881"},{"key":"2024102021475498000_43.4.1003.30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808836"},{"key":"2024102021475498000_43.4.1003.31","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00165410"},{"key":"2024102021475498000_43.4.1003.32","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.563213"},{"key":"2024102021475498000_43.4.1003.33","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.3.2002117"},{"key":"2024102021475498000_43.4.1003.34","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200210-1233OC"},{"key":"2024102021475498000_43.4.1003.35","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01562-0"},{"key":"2024102021475498000_43.4.1003.36","first-page":"67","article-title":"Pulmonary emphysema with special reference to vascular changes","volume":"80","author":"Leibow","year":"1959","journal-title":"Am Rev Respir Dis"},{"key":"2024102021475498000_43.4.1003.37","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200707-980OC"},{"key":"2024102021475498000_43.4.1003.38","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.F269"},{"key":"2024102021475498000_43.4.1003.39","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2002-0228OC"},{"key":"2024102021475498000_43.4.1003.40","doi-asserted-by":"publisher","DOI":"10.1038\/nm1238"},{"key":"2024102021475498000_43.4.1003.41","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.46.33143"},{"key":"2024102021475498000_43.4.1003.42","doi-asserted-by":"publisher","DOI":"10.1038\/nm1211"},{"key":"2024102021475498000_43.4.1003.43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704576200"},{"key":"2024102021475498000_43.4.1003.44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103187108"},{"key":"2024102021475498000_43.4.1003.45","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.109.882696"},{"key":"2024102021475498000_43.4.1003.46","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf113"},{"key":"2024102021475498000_43.4.1003.47","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/oxfordjournals.aje.a115184","article-title":"The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives","volume":"129","author":"The ARIC investigators","year":"1989","journal-title":"Am J Epidemiol"},{"key":"2024102021475498000_43.4.1003.48","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(91)90005-W"},{"key":"2024102021475498000_43.4.1003.49","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.34.4.553"},{"key":"2024102021475498000_43.4.1003.50","doi-asserted-by":"publisher","DOI":"10.1016\/0091-7435(75)90037-7"},{"key":"2024102021475498000_43.4.1003.51","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90080-7"},{"key":"2024102021475498000_43.4.1003.52","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.0170"},{"issue":"Suppl. 6","key":"2024102021475498000_43.4.1003.53","first-page":"1","article-title":"The Jackson Heart Study: an overview","volume":"15","author":"Taylor","year":"2005","journal-title":"Ethn Dis"},{"key":"2024102021475498000_43.4.1003.54","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200409000-00001"},{"key":"2024102021475498000_43.4.1003.55","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-4-201002160-00004"},{"key":"2024102021475498000_43.4.1003.56","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9712108"},{"key":"2024102021475498000_43.4.1003.57","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-011-1071-0"},{"key":"2024102021475498000_43.4.1003.58","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws169"},{"key":"2024102021475498000_43.4.1003.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2008.12.024"},{"key":"2024102021475498000_43.4.1003.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.12.038"},{"key":"2024102021475498000_43.4.1003.61","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"2024102021475498000_43.4.1003.62","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp710"},{"key":"2024102021475498000_43.4.1003.63","doi-asserted-by":"publisher","DOI":"10.1038\/ng1847"},{"key":"2024102021475498000_43.4.1003.64","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq340"},{"key":"2024102021475498000_43.4.1003.65","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm","year":"1979","journal-title":"Scand J Stat"},{"key":"2024102021475498000_43.4.1003.66","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq419"},{"key":"2024102021475498000_43.4.1003.67","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.10.041"},{"key":"2024102021475498000_43.4.1003.68","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2011.43.11.068"},{"key":"2024102021475498000_43.4.1003.69","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.44.31286"},{"key":"2024102021475498000_43.4.1003.70","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2008.11.003"},{"key":"2024102021475498000_43.4.1003.71","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.24.14196"},{"key":"2024102021475498000_43.4.1003.72","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.08.049"},{"key":"2024102021475498000_43.4.1003.73","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200906-0826OC"},{"key":"2024102021475498000_43.4.1003.74","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200401010"},{"key":"2024102021475498000_43.4.1003.75","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-127928"},{"key":"2024102021475498000_43.4.1003.76","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.02.023"},{"key":"2024102021475498000_43.4.1003.77","doi-asserted-by":"publisher","DOI":"10.1038\/ng1161"},{"key":"2024102021475498000_43.4.1003.78","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20882"},{"key":"2024102021475498000_43.4.1003.79","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-10-5"},{"key":"2024102021475498000_43.4.1003.80","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054013"},{"key":"2024102021475498000_43.4.1003.81","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.25790"},{"key":"2024102021475498000_43.4.1003.82","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.144055"},{"key":"2024102021475498000_43.4.1003.83","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61770-X"},{"key":"2024102021475498000_43.4.1003.84","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1201832"},{"key":"2024102021475498000_43.4.1003.85","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.986"},{"key":"2024102021475498000_43.4.1003.86","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60312-2"},{"key":"2024102021475498000_43.4.1003.87","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706628"},{"key":"2024102021475498000_43.4.1003.88","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1206797"},{"key":"2024102021475498000_43.4.1003.89","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M700471-JLR200"},{"key":"2024102021475498000_43.4.1003.90","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn721"},{"key":"2024102021475498000_43.4.1003.91","doi-asserted-by":"publisher","DOI":"10.1101\/gr.5120106"},{"key":"2024102021475498000_43.4.1003.92","doi-asserted-by":"publisher","DOI":"10.1038\/ng.273"},{"key":"2024102021475498000_43.4.1003.93","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(81)90113-X"},{"key":"2024102021475498000_43.4.1003.94","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.12.010"},{"key":"2024102021475498000_43.4.1003.95","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.9.842"},{"key":"2024102021475498000_43.4.1003.96","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00112411"},{"key":"2024102021475498000_43.4.1003.97","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.10.003"},{"key":"2024102021475498000_43.4.1003.98","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2010.10.010"},{"key":"2024102021475498000_43.4.1003.99","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.132688"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00147612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:45:00Z","timestamp":1740379500000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00147612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,30]]},"references-count":99,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,3,31]]},"published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1183\/09031936.00147612"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00147612","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,30]]}}}