{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:24:41Z","timestamp":1774124681700,"version":"3.50.1"},"reference-count":48,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2007,1,20]]},"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>The comparative effectiveness and safety of macrolides, quinolones and amoxicillin\/clavulanate (A\/C) for the treatment of patients with acute bacterial exacerbation of chronic bronchitis (ABECB) was evaluated in the present study.<\/jats:p><jats:p>PubMed, Current Contents and the Cochrane Central Register of Controlled Trials were searched to identify relevant randomised controlled trials (RCTs).<\/jats:p><jats:p>In total, 19 RCTs (20 comparisons) were included in the present analysis. There was no difference regarding treatment success in intention-to-treat and clinically evaluable patients between macrolides and quinolones, A\/C and quinolones or A\/C and macrolides. The treatment success in microbiologically evaluable patients was lower for macrolides compared with quinolones (odds ratio (OR) 0.47, 95% confidence interval (CI) 0.31\u20130.69). Fewer quinolone-recipients experienced a recurrence of ABECB after resolution of the initial episode compared with macrolide-recipients during the 26-week period following therapy. Adverse effects in general were similar between macrolides and quinolones. Administration of A\/C was associated with more adverse effects (mainly diarrhoea) than quinolones (OR 1.36, 95% CI 1.01\u20131.85).<\/jats:p><jats:p>Macrolides, quinolones and amoxicillin\/clavulanate may be considered equivalent for the treatment of patients with an acute bacterial exacerbation of chronic bronchitis in terms of short-term effectiveness. Quinolones are associated with better microbiological success and fewer recurrences of acute bacterial exacerbation of chronic bronchitis than macrolides, while amoxicillin\/clavulanate is associated with more adverse effects than both comparators.<\/jats:p>","DOI":"10.1183\/09031936.00147806","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T01:18:52Z","timestamp":1171502332000},"page":"1127-1137","source":"Crossref","is-referenced-by-count":43,"title":["Macrolides, quinolones and amoxicillin\/clavulanate for chronic bronchitis: a meta-analysis"],"prefix":"10.1183","volume":"29","author":[{"given":"I. I.","family":"Siempos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Dimopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. P.","family":"Korbila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Manta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Falagas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2007,2,14]]},"reference":[{"key":"2024102019144683000_29.6.1127.1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.2_Supplement.123S"},{"key":"2024102019144683000_29.6.1127.2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-106-2-196"},{"key":"2024102019144683000_29.6.1127.3","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.3.2010017"},{"key":"2024102019144683000_29.6.1127.4","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.5.9709032"},{"key":"2024102019144683000_29.6.1127.5","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2002.1334"},{"key":"2024102019144683000_29.6.1127.6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03470010084035"},{"key":"2024102019144683000_29.6.1127.7","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.4.8887592"},{"key":"2024102019144683000_29.6.1127.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605303342206"},{"key":"2024102019144683000_29.6.1127.9","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.5.9711044"},{"key":"2024102019144683000_29.6.1127.10","first-page":"CD004403","volume":"2","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"2024102019144683000_29.6.1127.11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520360071042"},{"key":"2024102019144683000_29.6.1127.12","doi-asserted-by":"publisher","DOI":"10.1086\/428058"},{"key":"2024102019144683000_29.6.1127.13","first-page":"3B","volume":"10","year":"2003","journal-title":"Can Respir J"},{"key":"2024102019144683000_29.6.1127.14","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.2008.S1"},{"key":"2024102019144683000_29.6.1127.15","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/43.suppl_1.107"},{"key":"2024102019144683000_29.6.1127.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)01085-X"},{"key":"2024102019144683000_29.6.1127.17","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"2024102019144683000_29.6.1127.18","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"2024102019144683000_29.6.1127.19","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"2024102019144683000_29.6.1127.20","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2002.1382"},{"key":"2024102019144683000_29.6.1127.21","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.3.953"},{"key":"2024102019144683000_29.6.1127.22","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.045930"},{"key":"2024102019144683000_29.6.1127.23","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/31.suppl_E.147"},{"key":"2024102019144683000_29.6.1127.24","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00106404"},{"key":"2024102019144683000_29.6.1127.25","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00009604"},{"key":"2024102019144683000_29.6.1127.26","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.3.772"},{"key":"2024102019144683000_29.6.1127.27","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(02)80045-5"},{"key":"2024102019144683000_29.6.1127.28","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(02)85139-6"},{"key":"2024102019144683000_29.6.1127.29","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.1999.0708"},{"key":"2024102019144683000_29.6.1127.30","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2000.0927"},{"key":"2024102019144683000_29.6.1127.31","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/44.4.501"},{"key":"2024102019144683000_29.6.1127.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2003.09.012"},{"key":"2024102019144683000_29.6.1127.33","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1177\/147323000102900408","volume":"29","year":"2001","journal-title":"J Int Med Res"},{"key":"2024102019144683000_29.6.1127.34","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1179\/joc.2000.12.4.314","volume":"12","year":"2000","journal-title":"J Chemother"},{"key":"2024102019144683000_29.6.1127.35","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(01)80031-X"},{"key":"2024102019144683000_29.6.1127.36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02850246","volume":"18","year":"2001","journal-title":"Adv Ther"},{"key":"2024102019144683000_29.6.1127.37","first-page":"141","volume":"9","year":"1997","journal-title":"Int J Antimicrob Agents"},{"key":"2024102019144683000_29.6.1127.38","doi-asserted-by":"publisher","DOI":"10.1177\/030006059702500105"},{"key":"2024102019144683000_29.6.1127.39","doi-asserted-by":"publisher","DOI":"10.1177\/030006059602400502"},{"key":"2024102019144683000_29.6.1127.40","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/37.1.93"},{"key":"2024102019144683000_29.6.1127.41","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1179\/joc.1995.7.2.146","volume":"7","year":"1995","journal-title":"J Chemother"},{"key":"2024102019144683000_29.6.1127.42","first-page":"85S","volume":"15","year":"1992","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2024102019144683000_29.6.1127.43","first-page":"1","volume":"59","year":"2004","journal-title":"Thorax"},{"key":"2024102019144683000_29.6.1127.44","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00055705"},{"key":"2024102019144683000_29.6.1127.45","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.3.811"},{"key":"2024102019144683000_29.6.1127.46","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200118010-00001"},{"key":"2024102019144683000_29.6.1127.47","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.1.40"},{"key":"2024102019144683000_29.6.1127.48","first-page":"CD001288","volume":"1","year":"2005","journal-title":"Cochrane Database of Syst Rev"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00147806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:02:42Z","timestamp":1740376962000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00147806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,14]]},"references-count":48,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2007,5,31]]},"published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1183\/09031936.00147806"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00147806","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,14]]}}}