{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:51:23Z","timestamp":1763967083723,"version":"3.37.3"},"reference-count":30,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,8,5]]},"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>We assessed whether exhaled nitric oxide fraction (<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>), a marker of eosinophilic airway inflammation, at 6 months was associated with the risk of wheezing during the first 2 yrs of life.<\/jats:p><jats:p>In the Generation R birth cohort, pre- and post-natal risk factors for respiratory morbidity and respiratory symptoms were assessed by questionnaires at 6 and 24 months. In 428 infants, off-line mixed oral\/nasal<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>was successfully measured during tidal breathing at 6 months. Complete data on<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>and respiratory symptoms within the first 6 months of life were available for 294 infants.<\/jats:p><jats:p><jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>was higher in males, was positively associated with age and was negatively associated with upper and lower respiratory symptoms within the first 6 months. Logistic regression analysis showed that for every ppb increase of<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>measured at 6 months, infants had a 1.06 (95% confidence interval 1.01\u20131.11)-fold increased risk of wheezing in the second year of life. High<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>(&gt;17.5 ppb) showed a limited added value in predicting wheezing in the second year.<\/jats:p><jats:p>We conclude that<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>at 6 months is positively associated with the risk of wheezing, but has limited added value in predicting wheezing in the second year of life in individual children.<\/jats:p>","DOI":"10.1183\/09031936.00151010","type":"journal-article","created":{"date-parts":[[2011,9,16]],"date-time":"2011-09-16T10:18:42Z","timestamp":1316168322000},"page":"567-572","source":"Crossref","is-referenced-by-count":15,"title":["Exhaled nitric oxide and the risk of wheezing in infancy: the Generation R 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