{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T19:39:03Z","timestamp":1779219543759,"version":"3.51.4"},"reference-count":31,"publisher":"European Respiratory Society (ERS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2009,11,4]]},"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>The hypothesis that T-cell interferon-\u03b3 responses to<jats:italic>Mycobacterium tuberculosis-<\/jats:italic>specific antigens decline as disease activity diminishes with tuberculosis (TB) treatment has generated interest in the interferon-\u03b3 release assays (IGRAs) as treatment-monitoring tools. We studied the effect of TB treatment on these responses as measured by the QuantiFERON-TB\u00ae Gold In-tube (QFT-IT) and T-SPOT.<jats:italic>TB<\/jats:italic>\u00ae assays.<\/jats:p><jats:p>275 sputum culture-positive, HIV-uninfected pulmonary TB patients were tested with QFT-IT and T-SPOT.<jats:italic>TB<\/jats:italic>\u00ae at baseline, treatment completion and 6 months thereafter. The QFT-IT was also performed at the end of the intensive phase. The time-treatment effect on the qualitative and quantitative IGRA results was determined.<\/jats:p><jats:p>There were significant declines in the positivity rates and quantitative results of both IGRAs with treatment. The QFT-IT positivity rate was significantly lower than the T-SPOT.<jats:italic>TB<\/jats:italic>\u00ae. The test reversion rate was significantly different for the two assays (13.9% for T-SPOT.<jats:italic>TB<\/jats:italic>\u00ae<jats:italic>versus<\/jats:italic>39.2% for QFT-IT). 79% and 46% tested positive with T-SPOT.<jats:italic>TB<\/jats:italic>\u00ae and QFT-IT respectively at 6 months post-treatment completion. The kinetics of the quantitative responses was not significantly different between subjects with and without risk factors for disease relapse.<\/jats:p><jats:p>That a substantial proportion of patients remained test-positive after TB treatment would suggest a limited role of IGRAs as treatment monitoring tools.<\/jats:p>","DOI":"10.1183\/09031936.00151309","type":"journal-article","created":{"date-parts":[[2009,11,20]],"date-time":"2009-11-20T02:58:05Z","timestamp":1258685885000},"page":"355-361","source":"Crossref","is-referenced-by-count":83,"title":["Tuberculosis treatment effect on T-cell interferon-\u03b3 responses to<i>Mycobacterium tuberculosis-<\/i>specific antigens"],"prefix":"10.1183","volume":"36","author":[{"given":"C.B.E.","family":"Chee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.W.","family":"Khinmar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.H.","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.M.","family":"Barkham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.K.","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.T.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"81","published-online":{"date-parts":[[2009,11,19]]},"reference":[{"key":"2024102020082217000_36.2.355.1","first-page":"49","article-title":"Centers for Disease Control and Prevention, Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tuberculosis infection. 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