{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:42:26Z","timestamp":1790232146055,"version":"4.1.0"},"reference-count":34,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2009,1,12]]},"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p>Data are lacking on the performance of interferon-\u03b3 release assays (IGRAs) in children. Although IGRAs are recommended for screening for latent tuberculosis infection (LTBI), many clinicians wish to employ them as a diagnostic test for active tuberculosis (TB). The objective of the present study was to compare the performance of the two commercially available IGRAs and the tuberculin skin test (TST) side-by-side in children with active TB and LTBI.<\/jats:p>\n                  <jats:p>In a prospective study, 209 children were investigated for active (n\u200a=\u200a91) or latent TB (n\u200a=\u200a118). TST, QuantiFERON-TB Gold In-tube (QFG-IT; Cellestis, Carnegie, Australia) and T-SPOT.TB (Oxford Immunotec, Abingdon, UK) assays were simultaneously used.<\/jats:p>\n                  <jats:p>For culture-confirmed active TB, the sensitivity of the TST was 83%, compared with 80% for QFG-IT and 58% for T-SPOT.TB. IGRAs did not perform significantly better than TST, although QFG-IT was significantly better than T-SPOT.TB. The agreement between QFG-IT and T-SPOT.TB in culture-confirmed TB was poor at 66.7%. In LTBI, the agreement between QFG-IT and T-SPOT.TB was very good (92%) with moderate agreement between TST and T-SPOT.TB (75%) and QFG-IT and TST (77%).<\/jats:p>\n                  <jats:p>A negative interferon-\u03b3 release assay should not dissuade paediatricians from diagnosing and treating presumed active tuberculosis. If used for diagnosis of latent tuberculosis infection, interferon-\u03b3 release assays could significantly reduce the numbers of children receiving chemoprophylaxis. Very good concordance between both tests was found.<\/jats:p>","DOI":"10.1183\/09031936.00153408","type":"journal-article","created":{"date-parts":[[2009,2,6]],"date-time":"2009-02-06T23:40:34Z","timestamp":1233963634000},"page":"1374-1382","source":"Crossref","is-referenced-by-count":124,"title":["Interferon-\u03b3 release assays do not identify more children with active tuberculosis than the tuberculin skin test"],"prefix":"10.1183","volume":"33","author":[{"given":"B.","family":"Kampmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Whittaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Walters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Martinez-Alier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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