{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:58:28Z","timestamp":1791284308941,"version":"4.1.0"},"reference-count":46,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2008,4,21]]},"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p>In patients with cystic fibrosis (CF) and non-CF bronchiectasis,<jats:italic>Pseudomonas aeruginosa<\/jats:italic>is the most important respiratory pathogen. It is able to synthesise hydrogen cyanide, a potent inhibitor of cellular respiration.<\/jats:p><jats:p>The present study investigated whether cyanide is present in the sputum of CF and non-CF bronchiectasis patients infected with<jats:italic>P. aeruginosa<\/jats:italic>, and whether the detection of cyanide affected lung function. Cyanide was measured in sputum using a cyanide ion selective electrode.<\/jats:p><jats:p>Cyanide was detected in sputum from 15 out of 25 CF and non-CF bronchiectasis patients with current<jats:italic>P. aeruginosa<\/jats:italic>infection; however, it was not detected in any of the 10 patients without this organism. Maximum levels were 130\u2005\u00b5M (mean\u00b1<jats:sc>se<\/jats:sc>72\u00b16.6\u2005\u00b5M). Concurrent lung function data were available on all 21<jats:italic>P. aeruginosa<\/jats:italic>-infected CF patients; the group with measurable sputum cyanide (n\u200a=\u200a11) was not different from those without (n\u200a=\u200a10) on the basis of age or sex. However, those with detectable cyanide had significantly poorer lung function than those without (forced expiratory volume in one second (% predicted) 26.8\u00b13.8<jats:italic>versus<\/jats:italic>46.0\u00b16.7%; forced vital capacity (% pred) 44.4\u00b14.9<jats:italic>versus<\/jats:italic>60.1\u00b17.7%).<\/jats:p><jats:p>Cyanide is detectable in sputum from cystic fibrosis and non-cystic fibrosis bronchiectasis patients infected with<jats:italic>Pseudomonas aeruginosa<\/jats:italic>, and is also associated with impaired lung function.<\/jats:p>","DOI":"10.1183\/09031936.00159607","type":"journal-article","created":{"date-parts":[[2008,5,15]],"date-time":"2008-05-15T00:34:58Z","timestamp":1210811698000},"page":"740-747","source":"Crossref","is-referenced-by-count":110,"title":["<i>Pseudomonas aeruginosa<\/i>, cyanide accumulation and lung function in CF and non-CF bronchiectasis patients"],"prefix":"10.1183","volume":"32","author":[{"given":"B.","family":"Ryall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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