{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:04:39Z","timestamp":1791284679541,"version":"4.1.0"},"reference-count":45,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2012,1,5]]},"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>After the age of 65 yrs the specific impact of unrecognised sleep-related breathing disorders (SRBD) on 24-h blood pressure (BP) levels remains under debate. We tested the cross-sectional relationship between the severity of obstructive sleep apnoea\/hypopnoea (OSAH) and the increase of BP using ambulatory BP monitoring (ABPM) in the PROOF (PROgnostic indicator OF cardiovascular and cerebrovascular events study)-SYNAPSE (Autonomic Nervous System Activity, Aging and Sleep Apnea\/Hypopnea study) cohort.<\/jats:p><jats:p>470 subjects (aged 68 yrs) neither treated for hypertension nor diagnosed for SRBD were included. All subjects underwent ABPM, and unattended at-home polygraphic studies. OSAH was defined by an apnoea\/hypopnoea index (AHI) &gt;15\u00b7h<jats:sup>\u22121<\/jats:sup>. The severity of the sleep apnoea was also quantified as the index of dips in oxyhaemoglobin saturation &gt;3% (ODI). Results are expressed in per protocol analysis.<\/jats:p><jats:p>Severe OSAH (AHI &gt;30\u00b7h<jats:sup>\u22121<\/jats:sup>, 17% of subjects) was associated with a significant 5 mmHg increase in both diurnal and nocturnal systolic BP (SBP), and with a nocturnal 3 mmHg increase in diastolic BP (DBP). Systolic (mean SBP &gt;135 mmHg) or diastolic (mean DBP &gt;80 mmHg) hypertension were more frequently encountered in subjects suffering from moderate (AHI 15\u201330) or severe OSAH. After adjustment, the independent association between severe OSAH and 24-h systolic hypertension remained significant (OR 2.42, 95% CI 1.1\u20135.4). The relationship was further reinforced when SRBD severity was expressed using ODI &gt;10\u00b7h<jats:sup>\u22121<\/jats:sup>.<\/jats:p><jats:p>The impact of unrecognised SRBD on BP levels also exists at the age of 68 yrs. The hypoxaemic load appears to be the pathophysiological cornerstone for such a relationship.<\/jats:p>","DOI":"10.1183\/09031936.00162710","type":"journal-article","created":{"date-parts":[[2012,4,21]],"date-time":"2012-04-21T03:04:14Z","timestamp":1334977454000},"page":"649-656","source":"Crossref","is-referenced-by-count":21,"title":["At 68 years, unrecognised sleep apnoea is associated with elevated ambulatory blood 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