{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:43:12Z","timestamp":1790318592709,"version":"4.1.0"},"reference-count":25,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2011,6,14]]},"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>The functional outcome in preschool severe wheezers with eosinophilic airway inflammation and increased reticular basement membrane (RBM) thickness is unknown. We investigated the relationship between airway pathology at age 2 yrs and lung function at age 4\u20136 yrs in previous severe wheezers.<\/jats:p><jats:p>Severe wheezers previously investigated by endobronchial biopsy and healthy children aged 4\u20136 yrs were recruited. Lung clearance index (LCI), conducting zone ventilation inhomogeneity (<jats:italic>S<\/jats:italic><jats:sub>cond<\/jats:sub>), acinar ventilation inhomogeneity by multiple-breath washout, plethysmographic-specific airway resistance and exhaled nitric oxide fraction (<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>) were measured. Lung function was compared between wheezers and healthy controls, and in wheezers correlated with past RBM thickness and mucosal eosinophilia (EG2+ cells).<\/jats:p><jats:p>72 healthy controls and 28 previous severe wheezers were tested. Wheezers had significantly higher median LCI (6.8<jats:italic>versus<\/jats:italic>6.6; p=0.001) and<jats:italic>S<\/jats:italic><jats:sub>cond<\/jats:sub>(0.046<jats:italic>versus<\/jats:italic>0.016; p&lt;0.0005) than healthy controls. Past RBM thickness (r=0.474, p=0.047) and EG2+ cells (r=0.552, p=0.041) showed significant correlations with current<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>, but no correlations were seen between past RBM thickness and current lung function.<\/jats:p><jats:p>RBM thickness and EG2+ cells at age 2 yrs show a significant positive association with<jats:italic>F<\/jats:italic><jats:sub>eNO<\/jats:sub>at age 5 yrs. Although lung function was abnormal at age 5 yrs in severe wheezers, this did not correlate with past RBM thickness.<\/jats:p>","DOI":"10.1183\/09031936.00164910","type":"journal-article","created":{"date-parts":[[2011,7,22]],"date-time":"2011-07-22T00:25:14Z","timestamp":1311294314000},"page":"1431-1436","source":"Crossref","is-referenced-by-count":38,"title":["Relationship between past airway pathology and current lung function in preschool wheezers"],"prefix":"10.1183","volume":"38","author":[{"given":"S.","family":"Sonnappa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.M.","family":"Bastardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Saglani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Aurora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2011,7,20]]},"reference":[{"key":"2024102020460472000_38.6.1431.1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.4.9912111"},{"key":"2024102020460472000_38.6.1431.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69286-6"},{"key":"2024102020460472000_38.6.1431.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.01.006"},{"key":"2024102020460472000_38.6.1431.4","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.3.242"},{"key":"2024102020460472000_38.6.1431.5","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.017244"},{"key":"2024102020460472000_38.6.1431.6","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1152\/jappl.2001.91.3.1035","article-title":"On the functional consequences of bronchial basement membrane thickening","volume":"91","author":"Milanese","year":"2001","journal-title":"J Appl Physiol"},{"key":"2024102020460472000_38.6.1431.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.018"},{"key":"2024102020460472000_38.6.1431.8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200702-212OC"},{"key":"2024102020460472000_38.6.1431.9","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-710ST"},{"key":"2024102020460472000_38.6.1431.10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-1061"},{"key":"2024102020460472000_38.6.1431.11","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00002108"},{"key":"2024102020460472000_38.6.1431.12","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00030605"},{"key":"2024102020460472000_38.6.1431.13","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200712-1818OC"},{"key":"2024102020460472000_38.6.1431.14","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.6.528"},{"key":"2024102020460472000_38.6.1431.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.09.029"},{"key":"2024102020460472000_38.6.1431.16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051378"},{"key":"2024102020460472000_38.6.1431.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69285-4"},{"key":"2024102020460472000_38.6.1431.18","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200205-414OC"},{"key":"2024102020460472000_38.6.1431.19","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.2.9907151"},{"key":"2024102020460472000_38.6.1431.20","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.6.9712073"},{"key":"2024102020460472000_38.6.1431.21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01656.x"},{"key":"2024102020460472000_38.6.1431.22","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200209-1030OC"},{"key":"2024102020460472000_38.6.1431.23","first-page":"233","article-title":"The role of small airway inflammation in asthma","volume":"23","author":"Tashkin","year":"2002","journal-title":"Allergy Asthma Proc"},{"key":"2024102020460472000_38.6.1431.24","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.2.405"},{"key":"2024102020460472000_38.6.1431.25","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2108069"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00164910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:31:35Z","timestamp":1740378695000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00164910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,20]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,11,30]]},"published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1183\/09031936.00164910"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00164910","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,20]]}}}