{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:20:44Z","timestamp":1781756444596,"version":"3.54.5"},"reference-count":28,"publisher":"European Respiratory Society (ERS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2008,6,22]]},"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:p>The aim of the present study was to evaluate the implementation of the 2003 Dutch guideline on the diagnosis and treatment of malignant pleural effusions, and the potential effect of the implementation on the clinical outcome of pleurodesis.<\/jats:p><jats:p>All patients with malignant pleural effusion who had a pleural drain placed with the intention of performing pleurodesis were registered prospectively in four centres. Details of the procedure and fluid recurrence and survival data were noted.<\/jats:p><jats:p>Patients with a proven malignancy (n\u200a=\u200a100) were entered into the registration database. Diagnostic guideline recommendations were followed in 60\u201370% of the patients. Surprisingly, pleurodesis was performed in only 75% of the patients, mainly due to the presence of a trapped lung. All pleurodeses were performed using talc, according to the guideline. Follow-up revealed fluid recurrence in 27 (36%) patients after a mean follow-up of 17\u2005days (range 2\u2013285\u2005days); 14 patients with successful pleurodesis died with a median survival of 61\u2005days (range 13\u2013174\u2005days). Systemic treatment following pleurodesis and good apposition of the pleural surfaces during drainage were good prognostic factors.<\/jats:p><jats:p>Despite reasonable-to-good adherence to the guideline, the number of successful pleurodeses was low. Better predictors of a good pleurodesis outcome are needed.<\/jats:p>","DOI":"10.1183\/09031936.00165607","type":"journal-article","created":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T00:24:54Z","timestamp":1215649494000},"page":"1321-1327","source":"Crossref","is-referenced-by-count":32,"title":["Pleural drainage and pleurodesis: implementation of guidelines in four hospitals"],"prefix":"10.1183","volume":"32","author":[{"given":"J. A.","family":"Burgers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. W. A.","family":"Kunst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. G. J.","family":"Koolen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. N. A.","family":"Willems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Burgers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"van den Heuvel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2008,7,9]]},"reference":[{"key":"2024102019401251000_32.5.1321.1","doi-asserted-by":"crossref","unstructured":"Shaw P, Agarwal R. Pleurodesis for malignant pleural effusions. Cochrane Database Syst Rev 2004; Issue 1:CD002916","DOI":"10.1002\/14651858.CD002916.pub2"},{"key":"2024102019401251000_32.5.1321.2","unstructured":"Groen H, Welling A, Postmus PE, van Meerbeeck JP, van Kasteren JHLM. Diagnostiek en behandeling van maligne pleuravocht. Richtlijn van de Nederlandse Vereniging van Artsen voor Longziekten en Tuberculose. [Diagnosis and Treatment of Malignant Pleural Effusions. Guideline of the Dutch Society of Pulmonologists.] Alphen aan den Rijn, van Zuiden Communications, 2003"},{"key":"2024102019401251000_32.5.1321.3","unstructured":"Dutch Institute for Healthcare Improvement CBO. Development of evidence-based clinical practice guidelines. www.cbo.nl\/product\/richtlijnen\/handleiding_ebro\/brochure_ebro_eng.pdf? Date last updated: 2006. 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Pleurodesis in patients with malignant pleural effusions: talc slurry or bleomycin? Results of a prospective randomized trial. 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