{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:24:50Z","timestamp":1791055490919,"version":"4.1.0"},"reference-count":32,"publisher":"European Respiratory Society (ERS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2010,3,22]]},"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>Obstructive sleep apnoea (OSA) has been linked to increased cardiovascular risk. The present study examined the relationships between respiratory parameters and left ventricular abnormalities in OSA.<\/jats:p><jats:p>150 newly diagnosed OSA patients without any known cardiovascular disease were included in the study (mean\u00b1<jats:sc>sd<\/jats:sc>age 49\u00b111 yrs, body mass index 27.1\u00b13.3 kg\u00b7m<jats:sup>\u22122<\/jats:sup>, respiratory disturbance index 41\u00b118 h<jats:sup>\u22121<\/jats:sup>). Haemodynamic, biological, respiratory, cardiac and arterial parameters were assessed at inclusion.<\/jats:p><jats:p>34 (22.7%) patients had a grade 1 left ventricular diastolic dysfunction. Patients with an abnormal diastole were older (p&lt;0.001) and 81% of them were hypertensive. The only respiratory parameter independently associated with the peak flow velocity in early diastole\/peak flow velocity at atrial contraction ratio was mean nocturnal oxygen saturation. 17 (13%) patients had left ventricular hypertrophy. A multivariate analysis showed that clinic systolic blood pressure and mean nocturnal oxygen saturation were independently associated with left ventricular hypertrophy. In a logistic regression model, age \u226558 yrs (OR 3.29, 95% CI 1.78\u20135.64) and mean nocturnal oxygen saturation &lt;92% (OR 2.76, 95% CI 1.45\u20134.91) were associated with left ventricular diastolic dysfunction.<\/jats:p><jats:p>Our findings demonstrate that left ventricular diastolic dysfunction frequently occurs in patients with OSA and that it is related to the severity of oxygen desaturation.<\/jats:p>","DOI":"10.1183\/09031936.00165709","type":"journal-article","created":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T00:20:46Z","timestamp":1277079646000},"page":"1323-1329","source":"Crossref","is-referenced-by-count":57,"title":["Left ventricular diastolic dysfunction is linked to severity of obstructive sleep apnoea"],"prefix":"10.1183","volume":"36","author":[{"given":"J-P.","family":"Baguet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Barone-Rochette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"L\u00e9vy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vautrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Pierre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Ormezzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-L.","family":"P\u00e9pin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2010,6,18]]},"reference":[{"key":"2024102020213516000_36.6.1323.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109080"},{"key":"2024102020213516000_36.6.1323.2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.1.9905035"},{"key":"2024102020213516000_36.6.1323.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005113421901"},{"key":"2024102020213516000_36.6.1323.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00184-0"},{"key":"2024102020213516000_36.6.1323.5","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000160207.58781.4e"},{"key":"2024102020213516000_36.6.1323.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71141-7"},{"key":"2024102020213516000_36.6.1323.7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118235"},{"key":"2024102020213516000_36.6.1323.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.02.021"},{"key":"2024102020213516000_36.6.1323.9","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.018739"},{"key":"2024102020213516000_36.6.1323.10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.21.2154"},{"key":"2024102020213516000_36.6.1323.11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.4.1085"},{"key":"2024102020213516000_36.6.1323.12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.501841"},{"key":"2024102020213516000_36.6.1323.13","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-005-0839-3"},{"key":"2024102020213516000_36.6.1323.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.11.054"},{"key":"2024102020213516000_36.6.1323.15","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.4.470"},{"key":"2024102020213516000_36.6.1323.16","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3281fc975a"},{"key":"2024102020213516000_36.6.1323.17","unstructured":"Rechtschaffen A Kales A . 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