{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:03:22Z","timestamp":1791025402123,"version":"4.1.0"},"reference-count":38,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2009,3,29]]},"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p>The aim of the present study was to compare the efficacy of 1\u2005yr of sibutramine-induced weight loss<jats:italic>versus<\/jats:italic>continuous positive airway pressure (CPAP) treatment on sleep-disordered breathing, cardiac autonomic function and systemic blood pressure in obese patients with obstructive sleep apnoea.<\/jats:p><jats:p>Subjects with a body mass index of \u226530\u2005kg\u00b7m<jats:sup>\u22122<\/jats:sup>without previous treatment for obstructive sleep apnoea underwent either sibutramine (n\u200a=\u200a22) or CPAP (n\u200a=\u200a18) treatment for 1\u2005yr.<\/jats:p><jats:p>Sibutramine induced a 5.4\u00b11.4\u2005kg decrease in body weight compared to the CPAP group, in which no changes in anthropometric variables were observed. The CPAP treatment improved all sleep and respiratory variables, whereas sibutramine-induced weight loss improved only nocturnal arterial oxygen saturation profile. Only CPAP treatment improved night-time systolic and diastolic blood pressure and 24-h and daytime ambulatory diastolic blood pressure. Sibutramine-induced weight loss had no impact on indices of heart rate variability, whereas CPAP treatment increased daytime time domain indices.<\/jats:p><jats:p>CPAP treatment for 1\u2005yr had beneficial impacts on nocturnal breathing disturbances, and improved nocturnal oxygenation, night-time systolic and diastolic blood pressure, and daytime cardiac parasympathetic modulation. Sibutramine did not improve sleep-disordered breathing, systemic blood pressure or heart rate variability. There were no adverse effects, such as increment in blood pressure or arrhythmias, associated with this treatment regimen.<\/jats:p>","DOI":"10.1183\/09031936.00167308","type":"journal-article","created":{"date-parts":[[2009,4,9]],"date-time":"2009-04-09T00:44:59Z","timestamp":1239237899000},"page":"694-701","source":"Crossref","is-referenced-by-count":40,"title":["Sibutramine<i>versus<\/i>continuous positive airway pressure in obese obstructive sleep apnoea 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