{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T16:52:38Z","timestamp":1794243158976,"version":"4.9.0"},"reference-count":52,"publisher":"European Respiratory Society (ERS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Respir J"],"accepted":{"date-parts":[[2014,1,8]]},"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>The origin(s) of systemic inflammation in patients with chronic obstructive pulmonary disease (COPD) is unclear. We investigated the impact of exposure to ambient air pollution on systemic biomarkers of inflammation (C-reactive protein (CRP), tumour necrosis factor-\u03b1, interleukin (IL)-6, IL-8 and fibrinogen) and tissue repair (hepatocyte growth factor (HGF)) in 242 clinically stable COPD patients (mean age 67.8 years and forced expiratory volume in 1 s 71.3% predicted) in Barcelona, Spain, in 2004\u20132006.<\/jats:p><jats:p>A spatiotemporal exposure assessment framework was applied to predict ambient nitrogen dioxide (NO<jats:sub>2<\/jats:sub>) and levels of particles with a 50% cut-off aerodynamic diameter of 2.5 \u03bcm (PM<jats:sub>2.5<\/jats:sub>) at each participant\u2019s home address during 10 periods of 24 h (lags 1\u201310) and 1 year prior to the blood sampling date. We used linear regression models to estimate associations between biomarkers and exposure levels.<\/jats:p><jats:p>An interquartile range (IQR) increase in NO<jats:sub>2<\/jats:sub>exposure in lag 5 was associated with 51%, 10% and 9% increases in CRP, fibrinogen and HGF levels respectively. We also observed 12% and 8% increases in IL-8 associated with an IQR increase in NO<jats:sub>2<\/jats:sub>exposure in lag 3 and over the year before sampling, respectively. These increases were larger in former smokers. The results for PM<jats:sub>2.5<\/jats:sub>were not conclusive.<\/jats:p><jats:p>These results show that exposure to ambient NO<jats:sub>2<\/jats:sub>increases systemic inflammation in COPD patients, especially in former smokers.<\/jats:p>","DOI":"10.1183\/09031936.00168813","type":"journal-article","created":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T05:02:45Z","timestamp":1392958965000},"page":"603-613","source":"Crossref","is-referenced-by-count":102,"title":["Air pollution and biomarkers of systemic inflammation and tissue repair in COPD patients"],"prefix":"10.1183","volume":"44","author":[{"given":"Payam","family":"Dadvand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Nieuwenhuijsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c0lvar","family":"Agust\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"de Batlle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Benet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Beelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Cirach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Hoek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Basaga\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Rodriguez-Roisin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Sauleda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep M.","family":"Ant\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Garcia-Aymerich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"81","published-online":{"date-parts":[[2014,2,20]]},"reference":[{"key":"2024102022341020000_44.3.603.1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.019588"},{"key":"2024102022341020000_44.3.603.2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200406-035MS"},{"key":"2024102022341020000_44.3.603.3","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.130260"},{"key":"2024102022341020000_44.3.603.4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037483"},{"key":"2024102022341020000_44.3.603.5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.5732"},{"key":"2024102022341020000_44.3.603.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2012.06.013"},{"key":"2024102022341020000_44.3.603.7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2147\/COPD.S5098","article-title":"Particulate matter air pollution exposure: role in the development and exacerbation of chronic obstructive pulmonary disease","volume":"4","author":"Ling","year":"2009","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2024102022341020000_44.3.603.8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1515\/reveh-2012-0012","article-title":"Effect of particulate matter air pollution on C-reactive protein: a review of epidemiologic studies","volume":"27","author":"Li","year":"2012","journal-title":"Rev Environ Health"},{"key":"2024102022341020000_44.3.603.9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00128106"},{"key":"2024102022341020000_44.3.603.10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00195811"},{"key":"2024102022341020000_44.3.603.11","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200507-1123OC"},{"key":"2024102022341020000_44.3.603.12","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0800194"},{"key":"2024102022341020000_44.3.603.13","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.11189"},{"key":"2024102022341020000_44.3.603.14","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10021"},{"key":"2024102022341020000_44.3.603.15","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-6-25"},{"key":"2024102022341020000_44.3.603.16","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.155358"},{"key":"2024102022341020000_44.3.603.17","first-page":"w13681","article-title":"Acute respiratory health effects of urban air pollutants in adults with different patterns of underlying respiratory disease","volume":"142","author":"Mehta","year":"2012","journal-title":"Swiss Med Wkly"},{"key":"2024102022341020000_44.3.603.18","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2010.90"},{"key":"2024102022341020000_44.3.603.19","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00120604"},{"key":"2024102022341020000_44.3.603.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2008.03.001"},{"key":"2024102022341020000_44.3.603.21","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.154484"},{"key":"2024102022341020000_44.3.603.22","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00014304"},{"key":"2024102022341020000_44.3.603.23","first-page":"217","article-title":"Spirometric reference values from a Mediterranean population","volume":"22","author":"Roca","year":"1986","journal-title":"Bull Eur Physiopathol Respir"},{"key":"2024102022341020000_44.3.603.24","doi-asserted-by":"publisher","DOI":"10.1159\/000205234"},{"key":"2024102022341020000_44.3.603.25","doi-asserted-by":"publisher","DOI":"10.1021\/es301948k"},{"key":"2024102022341020000_44.3.603.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.atmosenv.2013.02.037"},{"key":"2024102022341020000_44.3.603.27","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2008.043471"},{"key":"2024102022341020000_44.3.603.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2011.07.002"},{"key":"2024102022341020000_44.3.603.29","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201204-0596PP"},{"key":"2024102022341020000_44.3.603.30","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/9.3.271"},{"key":"2024102022341020000_44.3.603.31","first-page":"695","article-title":"In-vitro-Expositionen einer humanen bronchialen Epithelzelllinie mit Stickstoffdioxid induzieren eine vermehrte Transkription und Freisetzung proinflammatorischer Zytokine [In vitro exposure of a human bronchial epithelial cell line with nitrogen dioxide induces enhanced transcription and liberation of pro-inflammatory cytokines]","volume":"49","author":"Kienast","year":"1995","journal-title":"Pneumologie"},{"key":"2024102022341020000_44.3.603.32","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.3488"},{"key":"2024102022341020000_44.3.603.33","doi-asserted-by":"publisher","DOI":"10.1136\/oem.57.12.818"},{"key":"2024102022341020000_44.3.603.34","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0800437"},{"key":"2024102022341020000_44.3.603.35","first-page":"763","article-title":"Effects of ozone on pulmonary function in normal subjects. An environmental-chamber study","volume":"111","author":"Kerr","year":"1975","journal-title":"Am Rev Respir Dis"},{"key":"2024102022341020000_44.3.603.36","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.155.1.9001299"},{"key":"2024102022341020000_44.3.603.37","first-page":"39","article-title":"Effects of ozone on normal and potentially sensitive human subjects. Part II: Airway inflammation and responsiveness to ozone in nonsmokers and smokers","volume":"78","author":"Frampton","year":"1997","journal-title":"Res Rep Health Eff Inst"},{"key":"2024102022341020000_44.3.603.38","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201010-1706OC"},{"key":"2024102022341020000_44.3.603.39","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201109-1695ED"},{"key":"2024102022341020000_44.3.603.40","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201006-0937OC"},{"key":"2024102022341020000_44.3.603.41","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-6-152"},{"key":"2024102022341020000_44.3.603.42","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2006.027995"},{"key":"2024102022341020000_44.3.603.43","doi-asserted-by":"publisher","DOI":"10.1186\/1476-072X-8-2"},{"key":"2024102022341020000_44.3.603.44","doi-asserted-by":"publisher","DOI":"10.1080\/00039899809605688"},{"key":"2024102022341020000_44.3.603.45","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.086827"},{"key":"2024102022341020000_44.3.603.46","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00162608"},{"key":"2024102022341020000_44.3.603.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2013.04.003"},{"key":"2024102022341020000_44.3.603.48","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2010.061135"},{"key":"2024102022341020000_44.3.603.49","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-11-48"},{"key":"2024102022341020000_44.3.603.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.atmosenv.2012.09.056"},{"key":"2024102022341020000_44.3.603.51","doi-asserted-by":"publisher","DOI":"10.1021\/es4008849"},{"key":"2024102022341020000_44.3.603.52","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200701-004FM"}],"container-title":["European Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1183\/09031936.00168813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:48:33Z","timestamp":1740379713000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.ersnet.org\/lookup\/doi\/10.1183\/09031936.00168813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,20]]},"references-count":52,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,8,31]]},"published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1183\/09031936.00168813"],"URL":"https:\/\/doi.org\/10.1183\/09031936.00168813","relation":{},"ISSN":["0903-1936","1399-3003"],"issn-type":[{"value":"0903-1936","type":"print"},{"value":"1399-3003","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,20]]}}}